Project Grant R01GM164639
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Johns Hopkins University a $426,250 Project Grant, effective March 1, 2026 through February 28, 2031, under the Biomedical Research and Research Training program (CFDA 93.859). This award funds research to investigate the mechanisms of translation regulation by examining single protein-mRNA interactions in live cells. The project establishes an advanced imaging system to visualize individual...
- Grant Award Summary The Johns Hopkins University received a $1,184,531 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025 through June 30, 2030. The research focuses on elucidating fundamental cellular processes governing gene expression and DNA repair mechanisms. The project investigates transcriptional regulation—including the initiation and regulation of...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Johns Hopkins University a $2.14 million Project Grant (CFDA 93.859: Biomedical Research and Research Training) effective September 1, 2025 through August 31, 2029 to conduct fundamental research on the molecular mechanisms of ribosome-mediated kinase signaling. The research project will investigate how ribosomes directly sense cellular stress and initiate downstream signaling pathways,...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Johns Hopkins University a Project Grant of $412,124 on March 18, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support fundamental research on mechanobiological regulations of collective cell movement. The research will be conducted in Baltimore, Maryland, through January 31, 2031, and aims to decode mechanical principles governing collective cell behaviors...
- Federal Grant Award Summary The Johns Hopkins University received a $1,199,593 Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074), awarded September 1, 2025, with a completion date of August 31, 2029. This grant supports fundamental research to advance understanding of nucleosome mobility and chromatin dynamics through single-molecule manipulation techniques. The project will develop and apply...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded Johns Hopkins University a Project Grant totaling $420,936 (awarded April 1, 2026, with completion targeted for March 31, 2031) under the Biomedical Research and Research Training program (CFDA 93.859). The research project investigates the mechanisms of protein self-assembly coupled to membrane mechanics in clathrin-mediated endocytosis (CME), a fundamental cellular transport pathway essential for...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded Johns Hopkins University a $414,709 Project Grant effective May 1, 2026 through February 28, 2031 under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports research to map the molecular architecture of biomolecular condensates using crosslinking mass spectrometry (XL-MS), a technique that captures protein structural information in native cellular contexts....
- Federal Project Grant Award Summary The Johns Hopkins University received a $406,026 Project Grant award effective March 5, 2026 through December 31, 2030 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports the development of biophysical theory and mathematical models to advance understanding of biomolecular condensate dynamics—non-membrane-bound cellular organelles that form through phase...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Johns Hopkins University a $426,479 Project Grant effective September 1, 2025 through August 31, 2030 under the Biomedical Research and Research Training program (CFDA 93.859). The award funds development of statistical and computational methods to synthesize genomic and clinical data from biobanks, electronic health records, and clinical registries for precision risk stratification and...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Johns Hopkins University a $454,478 Project Grant (CFDA 93.859: Biomedical Research and Research Training) on September 10, 2025, to support research through August 31, 2030. The grant funds technology development to advance understanding of the glycan-protein interactome—the complex interactions between sugar structures (glycans) on cell surfaces and their protein binding partners. The research...
The National Institute of General Medical Sciences (NIGMS) awarded The Johns Hopkins University a $326,463 Project Grant on June 8, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The research project, titled "Live-Cell Functions of Histone PTM Readers and Histone H2A.Z Variant in Epigenetic Regulation of Transcription," will be conducted through March 31, 2030, at the institution's Baltimore, Maryland facility. This award funds fundamental biomedical research investigating the physiological mechanisms by which histone post-translational modification (PTM) readers and the histone variant H2A.Z regulate eukaryotic gene expression through chromatin architecture and transcription factor dynamics. The project will deliver three research components: (1) investigation of histone PTM reader roles in targeting chromatin remodeling complexes (SWR1, INO80, and SWI/SNF); (2) characterization of H2A.Z's impact on transcription initiation and elongation factor recruitment; and (3) analysis of H2A.Z's role in transcription bursting using live-cell single-RNA imaging. The research employs integrated quantitative single-molecule tracking, genomic mapping, and genetic perturbation methodologies in budding yeast to elucidate how chromatin-associated factors dynamically regulate transcription. Findings will advance fundamental understanding of eukaryotic gene regulation with potential implications for disease-related transcriptional dysregulation.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $326.5k | 6/9/26 |