Project Grant R35GM158347
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $380,587 to The Johns Hopkins University from January 1, 2025 to December 31, 2029. The project aims to develop new integrated technologies to investigate how distinct molecular programs drive cell behaviors and cellular responses to perturbations at single-cell resolution. The research will focus on understanding...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $387,500 Project Grant to The Johns Hopkins University on May 1, 2025. The funding supports a research program that systematically investigates the roles of conserved microRNAs during animal development. The research leverages the experimental system provided by C. elegans, utilizing state-of-the-art molecular biology and genetics approaches. The...
- This federal Project Grant award of $387,500.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research to determine the molecular mechanisms that regulate the activity of protein kinases. The research will use the Hippo pathway, which controls decisions of cell fate and number, as a model system to investigate different mechanisms that modulate the activity of protein kinases. The goal is to accelerate the...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $450,313 in funding to The Johns Hopkins University from June 1, 2025 to May 31, 2030. The project aims to elucidate the molecular mechanisms and protein dynamics that enable the engineering of nonribosomal peptide synthetases (NRPSs), multidomain enzymatic factories that produce complex natural products with...
- This federal Project Grant award of $617,007 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on the molecular mechanisms of DNA double-strand break repair through non-homologous end joining (NHEJ). The research aims to elucidate how DNA ends are held together and coordinated with end processing enzymes to maximize the fidelity of NHEJ and minimize genome alterations. The...
- The National Institute of General Medical Sciences (NIGMS) awarded a $854,927 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Washington University in Missouri. The grant, effective September 5, 2025 through August 31, 2027, will support research to define the mechanisms of a new pathway for genome stability, known as RNA Damage Induced DNA Breaks (RDIBS). The key objectives are to identify the types of RNA modifications that activate RDIBS, the...
- The National Institute of General Medical Sciences (NIGMS) awarded a $492,000 Project Grant with the CFDA program title "Biomedical Research and Research Training" to St. John's University, New York. The grant supports a 3-year research project investigating how the checkpoint kinases Mec1p and Rad53p regulate transcription termination, particularly the role of these kinases in pre-mRNA 3' end processing and the NRD1-NAB3-SEN1 (NNS) termination pathway. The research aims to elucidate...
- The Johns Hopkins University was awarded a $2,136,693 Project Grant from the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training program) to conduct research on the "Molecular Mechanisms of Ribosome-Mediated Kinase Signaling". The 4-year project, which commenced on September 1, 2025, aims to define the molecular mechanisms by which two specific cellular kinases, GCN2 and ZAK, interact with ribosomes to activate downstream stress...
- This federal Project Grant award of $390,000.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to elucidate the mechanisms underlying DNA double-strand break repair at Thomas Jefferson University, doing business as Sidney Kimmel Medical College. The research aims to determine the regulatory mechanisms of the multi-protein and multi-step process required to coordinate the repair of DNA...
- This $363,800 Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research by The Johns Hopkins University investigating how supercoiled DNA impacts transcription, a core process of life that converts genetic information into RNA. The research will: Characterize how supercoiling affects transcription kinetics and correlation using in vitro single-molecule imaging of purified proteins and DNA constructs. Determine how chromosomal...
The National Institute of General Medical Sciences (NIGMS) awarded a $525,416 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Johns Hopkins University. This 5-year grant supports fundamental scientific research focused on two key cellular processes: the regulation of gene expression through transcription and the repair of DNA damage using the non-homologous end joining (NHEJ) pathway. The research aims to elucidate the intricate mechanisms behind these critical cellular functions, employing advanced imaging and molecular techniques. The findings have implications for developing new therapeutic strategies for diseases related to gene expression errors and DNA repair defects. The Johns Hopkins University, a leading federal contractor and grantee, will conduct this research at its facilities in Maryland, leveraging its expertise in biomedical research, medical innovation, and scientific consultation across various domains.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $525.4k | 8/13/25 |