This $380,540 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to decipher new principles of rapid proteostatic control and develop spatiotemporal lysosomal tools. The key research activities include: 1) defining novel protein substrates and motifs required for lysosomal delivery, 2) determining the functional impact of methyl-driven lysosomal proteolysis on...
This federal Project Grant award, with ID R35GM154651, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The $381,250 award, effective September 1, 2024 through August 31, 2029, will support research at the University of New Mexico Health Sciences Center (UNM HSC) to investigate the cellular mechanisms underlying the response to lysosomal damage. The research aims to establish the function of...
The National Institute of General Medical Sciences (NIGMS) awarded a $382,616 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) program to New Mexico State University (NMSU). The 5-year grant, effective June 1, 2025 through March 31, 2030, will support research to elucidate the structure, function, and mechanism of bacterial zinc ATP-binding cassette (ABC) transporters. This work aims to develop a better understanding of these critical virulence factors in...
This Project Grant award of $769,644 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research to functionally characterize the lysosome membrane and its protein quality control system. The primary objectives are to: 1) identify substrates of lysosomal E3 ligases in humans, 2) investigate the assembly of the ESCRT machinery to the lysosome membrane for internalizing ubiquitinated cargoes, and 3) determine the...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $502,043 in funding to Brandeis University. The research program aims to investigate how transition metals shape catalysis and allostery in metalloproteins, focusing on two key enzyme superfamilies: viral proteases and SAMHD1 dNTPases. The project will dissect the metal-dependent activities of viral proteases from...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training federal grant program (CFDA 93.859), is funding research by The Ohio State University to investigate lysosomal membrane dynamics under stress conditions. The $393,750 award, which runs from February 1, 2025 to January 31, 2030, aims to provide a better mechanistic understanding of lysosomal quality control and potential therapeutic applications. Key...
This federal Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to understand the novel enzymatic function of histone H3 as a copper reductase. The $433,125 award, with a project period from July 1, 2025 to April 30, 2030, is provided to the University of California, Los Angeles (UCLA) to conduct structural and functional studies on the copper reductase activity...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $364,324 to the Regents of the University of Michigan to conduct research on sulfide-regulated copper metabolism. The project aims to characterize how hydrogen sulfide (H2S), a signaling molecule, impacts copper metabolism and the activity of the copper-containing Complex IV in the electron transport chain, particularly in...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $114,300.00 to The Regents of the University of Colorado, doing business as the University of Colorado-Denver, for a project titled "High-Throughput Experimental and Computational Identification of RNA Elements that Regulate Trafficking to Midbodies". The project aims to use high-throughput experimental techniques, single...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $411,250 to The Trustees of Columbia University in the City of New York to conduct research on the interactions between membrane-bound organelles, such as lysosomes, and membrane-less organelles, such as RNA granules. The overarching goal is to understand how these two types of cellular compartments coordinate to maintain RNA...