Project Grant R35GM158359
- This Project Grant award of $501,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research by The Regents of the University of California, San Francisco (UCSF) to develop simulation-based models that can more accurately interpret experimental data in structural biology. The goal is to enhance understanding of how macromolecules communicate and interact, which is vital for advancing...
- This Project Grant award of $638,334 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to advance the understanding of structural mechanisms underlying protein-small molecule binding and protein function. The project will develop novel computational methods for thermodynamic mapping of proteins, ligands, and surrounding aqueous solvent using molecular dynamics simulations. The goal is to create a...
- This Project Grant award of $356,423.00 was provided on May 15, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports research focused on three main objectives: (a) developing accurate and efficient quantum mechanical (QM) methods based on density functional theory (DFT) for modeling biomolecular interactions, (b) constructing improved protein and biomolecular force fields using...
- The University of Colorado-Denver was awarded a $1,998,288 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The 4-year grant, commencing on September 1, 2025, will support research to investigate the kinetics of co-translational protein folding in living cells using a novel visualization technology. Specifically, the project aims to quantify co-translational folding in diverse intracellular...
- This federal Project Grant award of $294,147 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to advance modeling of macromolecular interactions in living cells. The key products and services to be delivered through this 5-year project (6/1/2025 - 5/31/2030) include: Characterization of the intermolecular energy landscapes for different types of macromolecules Simulation of macromolecular interactions...
- This $298,435 federal Project Grant award from the National Science Foundation Division of Materials Research under the Mathematical and Physical Sciences program (CFDA 47.049) aims to provide the research community with a robust and versatile computational framework for accurate modeling of mesoscale bionano systems. Specifically, the project transforms the Atomic Resolution Brownian Dynamics (ARBD) code into a general-purpose mesoscale simulation engine supporting parallel computing on...
- This $254,182 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will fund the development of a novel, unified X-ray/cryo-EM pipeline for ensemble-based structural refinement. The project aims to address the significant challenges posed by structural disorder, flexibility, and conformational heterogeneity in modern therapeutic modalities, which limit the accuracy of traditional refinement...
- This federal Project Grant award of $329,976 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to establish a multiscale modeling strategy to simulate ion selectivity in proteins. The principal investigator will utilize novel force fields to conduct molecular dynamics simulations that provide structural, dynamic, and thermodynamic insights into protein-ion interactions. The research aims to analyze the...
- The National Institute of General Medical Sciences (NIGMS) awarded a $2,113,889 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Colorado, Boulder. This 4-year grant, running from September 1, 2025 to August 31, 2029, focuses on enhancing cryogenic sample time-resolved electron microscopy (CryoTREM) capabilities through the development of a patterned LED/LCD-based illumination system. The goal is to capture multiple temporal states of...
- This federal Project Grant award of $2,053,480.00 was provided by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), to The Regents of the University of Colorado, doing business as the University of Colorado-Denver. The project aims to develop a novel framework for analyzing pathway interactions and pathway-phenotype associations in bulk and single-cell RNA sequencing (RNA-seq) studies. The key products or...
This federal Project Grant award, valued at $404,490.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The primary awardee, The Regents of the University of Colorado, will use the funding to develop systematically improvable force fields that achieve high accuracy and broad coverage of NIH-relevant chemistry. This work aims to address challenges in modeling protein-ligand binding phenomena related to human health, such as targeting protein-protein interfaces, kinases, phosphatases, and short peptide interaction motifs. The project will leverage the awardee's expertise in biophysical modeling and drug design to build force fields that can be broadly applied across high-performance software packages. This effort is part of a collaboration with the Open Force Field Initiative to advance computational tools for new pharmaceutical paradigms.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $404.5k | 8/21/25 |