Project Grant R01GM152459

Award Date 9/10/24
Completion Date 8/31/29
Dollars Obligated $351K
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Minneapolis, MN 55455, USA
Similar Awards
This Project Grant award, valued at $372,210.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The funding will support research at San Diego State University Foundation to develop synthetically modified, fluorescent nucleosides and oligonucleotides. The goals of this research program are to: (1) create fluorescent probes to image the uptake and endosomal escape of therapeutic...
This Project Grant award of $388,621 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support the development of novel molecular designs with therapeutic potential. The key objectives are: Developing ligand-heterocycle conjugates as targeted RNA degraders with rapid kinetics and selectivity for cancer-associated G-quadruplexes. Engineering nucleic acid polymers with (thio)phosphoramidate backbones as biostable...
This $402,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop a novel approach that combines modular fluorophores and correlative super-resolution microscopy to investigate the structure, dynamics, and interactome of biomolecular condensates in bacteria. The project, being conducted at New York University, will apply this "opto-proteomic toolbox" to understand the role of...
This Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), is funding the development of novel signal amplification technologies by Molecular Instruments, Inc. to enable automated, ultrasensitive, and multiplex imaging of RNA and protein expression in biological samples. The $1,099,625 award supports the engineering of two key capabilities: 1) a chromogenic signal amplification...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $762,960 to the University of Texas at Austin to develop localized real-time sensors for monitoring intracellular metabolic signaling. The research aims to deconvolute the signaling roles of metabolites by creating genetically encoded fluorescent biosensors that can measure specific metabolite concentrations and fluctuations within...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) in the amount of $364,969 will fund the development of a toolbox of switchable and functional fluorescent probes for multi-functional super-resolution microscopy (MF-SRM). The overarching goal is to enable new experimental and computational studies in the fields of chromatin epigenetics and spatially-resolved multi-omics by decoding...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $335,712 to the University of New Mexico to develop advanced imaging techniques for studying protein interactions and organizations in cells. The primary objectives are to: 1) Develop high-resolution two-color single-particle tracking (SPT) methods to investigate dimer formation and dissociation, and 2) Create a...
This $300,477 federal Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The award will support a 5-year research project focused on investigating the molecular regulation of cell protrusion function in 3D environments. The research aims to develop computational algorithms based on computational geometry to reconstruct plasma membrane organization from 3D microscopy images and...
This Project Grant award, totaling $432,834, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training federal grant program (CFDA 93.859). The award supports the development of an "enzyme-free, label-free quantitative microarray technology" to enable highly sensitive and quantitative measurement of small nucleic acid targets, such as microRNAs, with applications in liquid biopsy diagnostics. The research strategy...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $424,264 in funding to the Regents of the University of Michigan from June 1, 2025 to May 31, 2030. The funding will support the development of advanced quantitative analysis methods for long-read RNA sequencing, both at the bulk and single-cell level. The goal is to enable deeper investigations of gene isoforms and their...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $350,635.00 in funding to the Regents of the University of Minnesota to develop new fluorescent aptamer tags for visualizing RNA in complex biological systems. The project aims to select fluorescent aptamers that do not form G-quadruplex structures, which can impair the use of aptamers as RNA imaging tags, particularly in eukaryotic and whole-organism settings. The research will focus on selecting non-G-quadruplex aptamers against azo dyes and endogenous pigments to enable robust live-cell RNA imaging, with the long-term goal of whole-organism RNA visualization. The project will utilize these new aptamer tags to characterize Lin28-mRNA interactions, which is not possible with existing G-quadruplex-forming aptamers. The award period runs from September 10, 2024, to August 31, 2029.

Generated 7/1/25, 4:40 AM