This $364,969 federal Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development of switchable and functional fluorophores for multi-functional super-resolution microscopy (MF-SRM) and spatially-resolved single-cell multi-omics. The grant aims to create a toolbox of fluorescent sensors as single-molecule functional probes to enable new experimental and computational studies in the...
The National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) awarded a $349,566 Project Grant to Biosensing Instrument Inc., a for-profit biotech company based in Tempe, Arizona. The funding will support the development of the Spotting-Free Nano-Oscillator Array (SFNOA) technology, an innovative platform for high-throughput, label-free quantification of ligand binding kinetics to transmembrane proteins in their native...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $350,635.00 in funding to the Regents of the University of Minnesota to develop new fluorescent aptamer tags for visualizing RNA in live cells and organisms. The key objectives are to select aptamers that do not form G-quadruplex structures, which can impair the use of existing aptamer tags in complex eukaryotic and whole-organism...
The National Institute of General Medical Sciences (NIGMS) awarded a $206,028 Project Grant (CFDA 93.859) to the University of Nevada, Reno to develop a redox-mediated approach for detecting individual antibody-nanoparticle conjugates. The goal is to create a rapid and selective electrochemical detection method for analyzing biomolecules, as an alternative to traditional immunoassay techniques. The key research objectives are: (1) developing a redox-mediated approach for antibody-nanoparticle...
The National Institute of General Medical Sciences (NIGMS) awarded a $313,520 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Regents of the University of Michigan. The grant supports the development of the RNP-MAP technology, a suite of novel live-cell chemical probing methods to map multi-protein networks on RNA, identify associated RNA-binding proteins, and measure transcriptome-wide RNA site-specific occupancy. This work aims to enable the...
The National Institute of General Medical Sciences (NIGMS) awarded a $539,550 Project Grant (CFDA 93.859 Biomedical Research and Research Training) to the Board of Regents of the University of Nebraska for a 5-year period from May 1, 2024 to April 30, 2029. The grant supports time-resolved structural studies of enzyme catalysis and regulation, with a focus on developing innovative structural biology methods to improve the understanding of fundamental enzymatic phenomena. The research aims to...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $295,923 to Avery Digital Data, Inc. to develop precision motion control and DNA fragment joining capabilities for an electronic nanochannel chip device. The goal is to greatly increase the availability of large, synthetic DNA constructs for biomedical researchers by creating a new, automated, and low-cost method of...
The federal Project Grant award R42GM154550 for $295,561.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). This grant supports the development of a commercial prototype "Plasmonic Scattering Microscopy (PSM)" instrument by Biosensing Instrument Inc., a for-profit manufacturer in Tempe, Arizona. The PSM technology is intended to enable high-throughput, label-free quantification of...
The National Institute of General Medical Sciences (NIGMS) awarded a $389,653 Project Grant (CFDA 93.859 Biomedical Research and Research Training) to The Research Foundation For The State University Of New York (RF-SUNY) at the University at Albany. The grant, which runs from January 1, 2025 to December 31, 2029, will support a multi-faceted research program focused on developing AI-assisted biosensors and precision therapeutics using DNA nanotechnology and synthetic biology. The key products...
The federal Project Grant award R35GM156895, in the amount of $349,681.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The award supports the development of two novel "force nanoprobes" that can be used to map intracellular forces in living cells, with a focus on understanding mechanical communication within the 3D genome. The first nanoprobe directly measures force by converting...