The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) to the Regents of the University of Minnesota in the amount of $350,635.00 on Sep 10, 2024. The project aims to develop new fluorescent aptamer tags for RNA visualization in complex biological systems like eukaryotic cells and whole organisms. The researchers will select non-G-quadruplex-forming aptamers against a range of azo dyes and...
This $1,539,200 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) supports the development of an integrated technology platform to characterize the conformational flexibility, heterogeneity, and dynamics of functional oligonucleotides. The key products to be delivered include: A novel ionization technique called Capillary Vibrating Sharp-Edge Spray Ionization (CVSSI) that...
This $370,190 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), aims to measure and understand the molecular mechanisms of viral nucleocapsid self-assembly and disassembly. The research will apply quantitative experimental methods, including interferometric scattering microscopy and cryo-electron microscopy, to a diverse set of RNA-packaging viruses. The goal is to uncover potentially...
This $462,500 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to develop chemical modulators of RNA-protein assemblies through the targeting of DEAD-box RNA-dependent ATPases. The research aims to generate selective inhibitors that can allosterically regulate RNA affinity, with the goal of propelling biological studies of RNA-protein complexes and potentially leading to...
This Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training Program) provides $388,621 to Rutgers, The State University to advance the development of novel small-molecule and nucleic acid therapeutics. The key products and services to be delivered under this 5-year grant include: Developing ligand-heterocycle conjugates as targeted RNA degraders with high selectivity for cancer-associated G-quadruplexes. Engineering...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop a new class of artificial RNA condensates, or "RNA organelles," to enable the spatial and temporal control of molecules within living cells. The $382,801 award, commencing on September 25, 2024 and concluding on August 31, 2029, will support research activities at the University of California, Los Angeles (UCLA) to: (1)...
The National Institute of General Medical Sciences (NIGMS) awarded North Carolina State University a $364,969 Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) to develop switchable and functional fluorophores for multi-functional super-resolution microscopy. The project aims to create a toolbox of fluorescent sensors as single-molecule functional probes to enable new experimental and computational studies in the fields of chromatin epigenetics and...
This $337,088 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development of a versatile RNA delivery platform tailored for the central nervous system (CNS). The project aims to establish a system with high-efficiency RNA delivery, precise cell-specific targeting, and minimal cellular disruption. Key technical objectives include engineering encapsulation capsids that release RNA cargo...
This $444,262 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research at the Massachusetts Institute of Technology (MIT) to develop new methods and reagents for synthesizing oligophosphate constructs. The key research objectives include: Advancing reagents and techniques for synthesizing oligophosphate chains of increasing length, up to hexaphosphate, heptaphosphate, and beyond. Enabling...
The National Institute of General Medical Sciences (NIGMS) awarded a $305,892 project grant under the Biomedical Research and Research Training Program (CFDA 93.859) to Dotquant LLC, a biotechnology research and development company. The grant funding will support the development of a new in vitro transcription kit that combines the benefits of wild-type T7 RNA polymerase (high efficiency and low cost) with the ability to incorporate chemically modified nucleotides, like those used in RNA...