This Project Grant award of $630,000 from the National Science Foundation's (NSF) Biological Sciences (CFDA 47.074) program will support the development of an advanced optical microscopy system at the University of New Mexico (UNM). The system will combine two recent breakthroughs in imaging techniques - MINFLUX and modal imaging - to enable unprecedented spatiotemporal resolution for studying protein interactions and oligomerization kinetics on living cell membranes. The research will focus...
This $1,444,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop new cryogenic electron microscopy (cryo-EM) methods to visualize the structural heterogeneity of ribosomes at the single-molecule level in cells. The award, effective September 2, 2024 through August 31, 2027, will enable the principal investigator to pursue strategies to extend a novel technique called 2D template...
This $402,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop a novel approach that combines modular fluorophores and correlative super-resolution microscopy to investigate the structure, dynamics, and interactome of biomolecular condensates in bacteria. The project, being conducted at New York University, will apply this "opto-proteomic toolbox" to understand the role of...
This $300,477 federal Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The award will support a 5-year research project focused on investigating the molecular regulation of cell protrusion function in 3D environments. The research aims to develop computational algorithms based on computational geometry to reconstruct plasma membrane organization from 3D microscopy images and...
This federal Project Grant award of $436,361 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of innovative tools and methods for probing the structure and dynamics of biological macromolecules using small and wide-angle X-ray scattering (SWAXS) analysis. The research program aims to significantly improve the resolution of density reconstruction from SWAXS data, develop new...
This $390,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) will support the development of a multiparametric fluorescence microscopy framework to correlate metabolic changes with cellular manipulations and physical/biophysical properties. The award, granted to Georgetown University, will establish a seamless workflow to quantify and correlate fundamental cellular interactions, such as...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,465,164 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Illinois. The grant supports the development of new super-accurate and super-resolved fluorescence microscopy techniques and probes for studying single molecular motors, such as kinesin, dynein, and myosin. Key focus areas include measuring conformational changes in these motors with nanometer and...
The National Institute of General Medical Sciences (NIGMS) awarded a $344,400 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The University of Texas Southwestern Medical Center to develop new tools and approaches for improving cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) imaging techniques. Specifically, the grant aims to: 1) Develop a sample preparation strategy to reduce electron-induced radiolysis of frozen-hydrated biological...
This Project Grant award, ID R35GM156443, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The $419,375 award, spanning January 1, 2025 to November 30, 2029, supports research at the University of New Mexico Health Sciences Center (UNM HSC) to define the functional dynamics of multidomain redox enzymes, with a focus on nitric oxide synthase (NOS) enzymes. The research aims to gain a comprehensive...
The National Institute of General Medical Sciences (NIGMS) awarded Vanderbilt University a $395,943 Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) with a performance period from September 1, 2024 to August 31, 2029. The goal of this research program is to develop new spectroscopic methods capable of providing enhanced insight into protein structure and dynamics within complex environments that impact human health. The key products and services to be...