Project Grant R01EY038046
- The National Eye Institute awarded Duke University $629,520 on September 1, 2026, under the Vision Research program (CFDA 93.867) to investigate the structural and functional roles of the cyclic nucleotide-gated (CNG) channel and sodium/potassium/calcium exchanger (NCKX) complex in maintaining photoreceptor outer segment integrity. The research addresses how photoreceptor cells construct and sustain their light-sensitive outer segment organelles—modified cilia containing stacked disc membranes...
- The National Eye Institute awarded Duke University $127,718 on December 21, 2025, under the Vision Research program (CFDA 93.867) to support cellular-level dissection of the visuomotor circuit in larval zebrafish, focusing on neural mechanisms that transform continuous visual motion signals into discrete motor commands. The research investigates how specific motion-selective neurons in the pretectum drive activation of recurrent inhibitory circuits composed of midbrain spinal projection neurons,...
- The National Eye Institute awarded Duke University $534,783 on July 1, 2026, through the Vision Research program (CFDA 93.867) to establish the Duke Ophthalmology Mentored Physician Scientist Program, a career development initiative for early-career ophthalmology physician scientists. The program will train two qualified physician scientist scholars per year through a five-year period of performance ending June 30, 2031. Training emphasizes multidisciplinary research in clinical,...
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded The University of Chicago $929,806 on September 30, 2025, under the Vision Research program (CFDA 93.867). The award funds research into synaptic development of the retinogeniculate pathway—the neural circuit connecting the eyes to the brain—with investigation focused on how neurons form correct connections during childhood development and how visual experience shapes that...
- The National Eye Institute awarded Duke University $405,373 on June 1, 2026, under the Vision Research program (CFDA 93.867) to characterize bicornuate cones, a novel type of cone photoreceptor cell discovered in the human retina that contains two fully developed outer segments emanating from a single inner segment. The project will conduct two specific aims. Aim 1 employs high-resolution ultrastructural analysis using three-dimensional electron tomography to determine the number of centrioles...
- The National Eye Institute, an office of the National Institutes of Health under the Department of Health and Human Services, awarded New York University $140,184 under the Vision Research program (CFDA 93.867) on July 1, 2026, to support research decoding the molecular logic of visual map formation in Drosophila. The award funds a career development and research project that investigates how spatial codes in developing photoreceptors guide topographic connectivity in downstream neural...
- The National Eye Institute awarded the University of California, Berkeley $143,031 on December 4, 2025, under the Vision Research program (CFDA 93.867) to computationally model the role of spatial phase in the selectivity and invariance of responses in primary visual cortex (V1) and secondary visual cortex (V2) to intermediate-level features in natural images. The modeling-driven research will investigate how phase-related computations operate across V1 and V2 and generate testable predictions...
- The National Eye Institute awarded the Regents of the University of Michigan $342,349 on August 1, 2026, under the Vision Research program (CFDA 93.867) to investigate the computational and neural mechanisms of visuocognitive adaptation. The research examines how the brain adaptively modulates visual and cognitive processes in response to environmental changes, fatigue, injury, and disease. The project tests whether error-based adaptation in spatial working memory and eye movements shares...
- The National Eye Institute awarded the University of California Irvine $388,206 on September 1, 2026, under the Vision Research program (CFDA 93.867) to develop VisionKB, a single-cell multi-omics knowledgebase for the visual system. The award funds three specific deliverables: construction of a curated single-cell multi-omics reference atlas of the eye; development of a code-free, collaborative data-analysis platform; and delivery of an AI-powered co-pilot for automated data access and...
- The National Eye Institute awarded Duke University $163,160 on February 8, 2027, under the Vision Research program (CFDA 93.867) to support research on the diversification of closely related bipolar cell types in retinal development. The funded research uses bipolar cells of the mouse retina as a model system to determine the developmental timing when bipolar cell types first become molecularly distinct and how these distinctions confer unique functional properties in mature types. The work...
The National Eye Institute awarded Duke University $485,871 for research on synaptic mechanisms of history-dependent visual processing under the Vision Research program (CFDA 93.867) beginning September 1, 2026. The award funds investigation of how adaptation dynamically regulates sensory systems in response to recent visual experience. The research examines cell-intrinsic, synaptic, and circuit mechanisms of adaptation in primary visual cortex across multiple timescales, testing the hypothesis that different neural mechanisms engage selectively based on temporal and spatial properties of sensory input. Aim 1 will employ whole-cell in vivo recordings to characterize how short-term depression, synaptic inhibition, and intrinsic conductances combine to shape visual processing, including causal approaches to determine mechanism engagement. Duke University's Office of Research Administration will conduct the work in Durham, North Carolina through May 31, 2030. This is a Project Grant, the standard assistance type for individual research proposals under NEI's portfolio. The award represents obligated funding and follows competitive merit review by the National Advisory Eye Council and NEI Director approval.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $485.9k | 8/27/26 |