Project Grant R01EY037893
- This Project Grant award from the National Eye Institute (NEI), part of the U.S. Department of Health and Human Services, provides $385,000.00 in funding to Wayne State University to conduct research on genetic and glial support mechanisms in acute and chronic models of photoreceptor degeneration. The research aims to understand, prevent, and treat vision-related conditions and diseases, a focus area of NEI's Vision Research federal grant program (CFDA 93.867). The study will compare...
- The National Eye Institute (NEI), under the federal Vision Research grant program (CFDA 93.867), awarded a $431,750 Project Grant to the University of Louisville to study the role of neurexin proteins in retinal structure and function. The grant, effective from September 1, 2025 to August 31, 2027, aims to 1) determine the function of three neurexin genes and their isoform-specific expression patterns within the retina, and 2) characterize the cell-type-specific expression of neurexin isoforms...
- This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research grant program (CFDA 93.867), provides $477,109.00 in funding to The University of Texas Southwestern Medical Center (UT Southwestern) to conduct research on gene regulation underlying photoreceptor neurodegeneration in retinal degenerative diseases. The project aims to determine how the transcriptional regulator PRDM13 regulates retinal development and its association with North Carolina macular...
- The National Eye Institute (NEI), under the U.S. Department of Health and Human Services, awarded a $606,092 Project Grant through the Vision Research program (CFDA 93.867) to The Regents of the University of California, doing business as the University of California, Berkeley (UC Berkeley). The grant, awarded on January 1, 2025, supports a 4-year research project to investigate the development of the preferred retinal locus (PRL) in individuals with central vision loss due to macular diseases...
- The U.S. National Eye Institute awarded a $1,397,496 Project Grant under its Vision Research federal grant program (CFDA 93.867) to The Leland Stanford Junior University. The grant, with an award date of August 1, 2025 and an ultimate completion date of March 31, 2030, will support research to identify the mechanism underlying the interplay between the loss of the ARMC9 gene and impaired mitochondrial function in the formation of cilia in Joubert Syndrome, a rare inherited form of retinal...
- This federal Project Grant award for $574,158.00 was provided by the National Eye Institute (CFDA 93.867 Vision Research) to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The award supports research to investigate the role of melanopsin, a light-sensitive protein, in the renewal of photoreceptor outer segments - a critical homeostatic process for maintaining visual function. The research aims to expand on preliminary findings demonstrating melanopsin's...
- The National Eye Institute (NEI), under the federal Vision Research grant program (CFDA 93.867), awarded a $595,302 project grant to Thomas Jefferson University, doing business as Sidney Kimmel Medical College, for the period of April 1, 2025 to March 31, 2030. The project aims to investigate how glucose and lactate support photoreceptor health and function in order to develop new treatment strategies to prevent vision loss. Specifically, the researchers will determine whether the retinal...
- This Project Grant award from the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) is funding research to develop an innovative gene therapy approach using self-amplifying and self-splicing RNA technologies. The $346,500 award, spanning September 2024 to September 2026, aims to evaluate the longevity, immunogenicity, and potential in vivo side effects of this novel mRNA-based therapy for treating inherited retinal dystrophies. The award recipient, The...
- The National Eye Institute (NEI) awarded a $437,310 Project Grant under the Vision Research federal grant program (CFDA 93.867) to the University of Rochester to conduct research on the molecular and physiological mechanisms of inner retinal remodeling in retinal degeneration. The research aims to elucidate the mechanisms behind genetic, morphological, and physiological changes in retinal ganglion cells that lead to decreased signal-to-noise ratio and corruption of retinal circuits, with the...
- The National Eye Institute (NEI) awarded a $421,136 Project Grant to the University of Maryland, College Park under the Vision Research federal grant program (CFDA 93.867) to explore a novel approach for correcting ocular opacities and enabling high-resolution fundus imaging. The 2-year project aims to demonstrate that neural-network based wavefront shaping can optically correct for ocular opacities, which degrade the performance of optical imaging techniques for the posterior segment of the...
This $1,369,974 Project Grant was awarded on September 15, 2025 by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) to the West Virginia University Research Corporation (WVURC). The funding supports a 3-year research project to investigate therapies for defects in protein networks essential for the development of photoreceptor outer segments, a key component of photoreceptor neurons responsible for vision. The research aims to identify an optimal therapeutic regimen and uncover the mechanisms by which the protein Prominin-1 (PROM1) contributes to outer segment morphogenesis. The project will employ a combination of AAV-mediated gene therapy in animal models, electrophysiological measurements, and biochemical analyses to address these objectives. The proposed research aligns with the NEI's strategic priority of leveraging genetic discoveries to elucidate disease mechanisms and accelerate therapy development for vision disorders.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.4m | 9/4/25 |