Project Grant R01EY036807
- Federal Grant Award Summary Baylor College of Medicine received a $646,167 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective April 1, 2026 through March 31, 2031. The award funds investigations into the cellular and molecular mechanisms underlying Age-Related Macular Degeneration (AMD), the leading cause of vision loss in elderly populations. The research applies high-throughput functional genomics approaches to identify causal...
- Federal Grant Award Summary Baylor College of Medicine received a $1,093,095 Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research program) effective July 1, 2025 through March 31, 2030, to investigate the role of vascular ligands and neurovascular dysfunction in glaucoma pathogenesis and to identify therapeutic targets for neuroprotection. The research leverages an innovative ligandomics technology platform to globally map cell-binding ligands with binding...
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded The Johns Hopkins University a $695,018 Project Grant effective August 1, 2025, through July 31, 2030, to conduct research on the regulation of retinal ganglion cell regeneration through Müller glia (MG) cell function. The award supports a five-year investigation into how MG cells function as injury-responsive stem cells to enable retinal regeneration, with the ultimate goal...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded Baylor College of Medicine a Project Grant of $120,902 under the Vision Research program (CFDA 93.867) for research on the mechanisms of axoglial interactions at the paranodal junction (PNJ). The project, which commenced on April 15, 2026 and concludes on March 31, 2028, focuses on understanding the molecular composition and functional significance of the paranodal junction—the largest intercellular junction in...
- Federal Project Grant Award Summary The Medical College of Wisconsin, Inc. received a $856,698 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded on July 1, 2025, with a project completion date of March 31, 2030. This award supports mechanistic research into retinal ganglion cell (RGC) genesis, addressing a critical gap in understanding the developmental factors necessary for generating these specialized neurons that serve as the sole...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded $255,340 through the Vision Research program (CFDA 93.867) to The Regents of the University of California, San Francisco for a five-year project (May 1, 2026 – April 30, 2031) focused on understanding and regenerating retinal ganglion cells in the vertebrate retina. This research addresses glaucoma, which affects over four million Americans and represents the second leading cause of irreversible blindness globally. The...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded The Schepens Eye Research Institute, Inc. a Project Grant of $545,948 under the Vision Research program (CFDA 93.867) to advance understanding of glaucoma pathophysiology. The award, effective April 1, 2026 through March 31, 2030, supports research investigating the role of reactive astrocytes in glaucoma progression and retinal ganglion cell (RGC) survival. The research aims to move beyond traditional neurocentric...
- Federal Grant Award Summary The University of Washington received a $458,288 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective May 1, 2026 through February 28, 2030. This five-year research initiative will advance regenerative therapies for retinal neuron loss by investigating methods to stimulate Müller glia cells to regenerate damaged retinal neurons in humans and non-human primates. The project will deliver research products...
- Federal Project Grant Award Summary The National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) awarded $902,000 to the University of California, San Francisco for a two-year project (September 1, 2025 – August 31, 2027) to conduct multimodal characterization of a novel inherited mouse model of glaucoma. The primary deliverables include comprehensive phenotypic characterization of GLIS1 knockout mice across two genetic backgrounds, evaluating structural and functional...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded The Johns Hopkins University a Vision Research grant (CFDA 93.867) totaling $173,286.17 to evaluate the regenerative potential of human retinal ganglion cells (RGCs). This project, which commenced June 1, 2025, addresses a critical barrier to vision restoration by investigating whether intrinsic factors regulating RGC survival and neurite outgrowth can be modulated to promote axonal regeneration and optic nerve...
Baylor College of Medicine received a $1.6 million project grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded September 30, 2025, with completion scheduled for September 29, 2028. The research investigates the molecular mechanisms governing Muller glial cell (MGC) reprogramming and proliferation through modulation of the Hippo and Wnt signaling pathways. The project aims to identify cellular and molecular strategies to reactivate the dormant regenerative capacity of the mammalian retina, which could lead to restoration of vision lost through retinal diseases including glaucoma, macular degeneration, and diabetic retinopathy, as well as traumatic injury. The research products will include empirical findings from genetic loss-of-function and gain-of-function experiments, fate mapping analyses, and single-cell transcriptomic data that precisely characterize the fate of proliferative MGCs and elucidate how retinal damage triggers MGC cell cycle entry. These data will provide critical insights into the mechanisms blocking mammalian MGC-mediated retinal regeneration and support the development of therapeutic strategies to bypass these inhibitory systems and restore mammalian retinal regenerative capacity.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 12/4/25 | ||
| Not listed | $1.6m | 9/28/25 |