Project Grant K99EY037780
- Federal Grant Award Summary Baylor College of Medicine received a $646,167 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective April 1, 2026 through March 31, 2031. The award funds investigations into the cellular and molecular mechanisms underlying Age-Related Macular Degeneration (AMD), the leading cause of vision loss in elderly populations. The research applies high-throughput functional genomics approaches to identify causal...
- Federal Grant Award Summary Baylor College of Medicine received a $1,093,095 Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research program) effective July 1, 2025 through March 31, 2030, to investigate the role of vascular ligands and neurovascular dysfunction in glaucoma pathogenesis and to identify therapeutic targets for neuroprotection. The research leverages an innovative ligandomics technology platform to globally map cell-binding ligands with binding...
- Federal Grant Award Summary Baylor College of Medicine received a $1.6 million project grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded September 30, 2025, with completion scheduled for September 29, 2028. The research investigates the molecular mechanisms governing Muller glial cell (MGC) reprogramming and proliferation through modulation of the Hippo and Wnt signaling pathways. The project aims to identify cellular and molecular strategies to...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded The Schepens Eye Research Institute, Inc. a Project Grant of $545,948 under the Vision Research program (CFDA 93.867) to advance understanding of glaucoma pathophysiology. The award, effective April 1, 2026 through March 31, 2030, supports research investigating the role of reactive astrocytes in glaucoma progression and retinal ganglion cell (RGC) survival. The research aims to move beyond traditional neurocentric...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded $255,722 under the Vision Research program (CFDA 93.867) to the University of California, Berkeley, effective September 15, 2025, through August 31, 2027. This Project Grant supports fundamental research investigating the role and regulation of optic nerve microglia in glaucomatous neuropathy. The research deliverables include scientific findings on how lipoxin B4 (LXB4), an endogenous lipoxin produced by retinal...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded The Washington University a $1,001,009 Vision Research (CFDA 93.867) Project Grant effective July 1, 2025, with a completion date of March 31, 2030. This award funds fundamental research investigating how visual signals for eye fixation and optokinetic reflex (OKR)—a reflexive eye movement triggered by peripheral visual motion—interact within the retina. The research directly addresses a significant gap in understanding...
- Summary of Federal Project Grant Award The National Eye Institute (NEI) awarded a $422,125 Project Grant to the University of Miami's Office of Research Administration—School of Medicine on August 1, 2025, under the Vision Research program (CFDA 93.867) for a two-year project period concluding July 31, 2027. This award funds research investigating cholesterol homeostasis as a therapeutic target for demyelinating eye diseases, which are pathologies affecting the optic nerve that can cause...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded The Johns Hopkins University a Project Grant totaling $199,122.50 (awarded June 1, 2025) under the Vision Research program (CFDA 93.867) to support fundamental research on starburst amacrine cells (SACs) in human retinal organoids. The project will deliver scientific research products including empirical findings on the developmental mechanisms and cellular connectivity of SACs, which are specialized interneurons critical to...
- Federal Project Grant Award Summary The National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) awarded $902,000 to the University of California, San Francisco for a two-year project (September 1, 2025 – August 31, 2027) to conduct multimodal characterization of a novel inherited mouse model of glaucoma. The primary deliverables include comprehensive phenotypic characterization of GLIS1 knockout mice across two genetic backgrounds, evaluating structural and functional...
- Federal Grant Award Summary Albert Einstein College of Medicine received a $414,711 Project Grant from the National Eye Institute (NEI) Vision Research program (CFDA 93.867), awarded June 1, 2025, with completion targeted for May 31, 2029. The award supports the development and utilization of a microphysiological system to elucidate mechanisms underlying early optic disc and stalk development, retinal ganglion cell (RGC) differentiation, axon growth, and pathfinding in human development and...
The National Eye Institute (NEI) awarded Baylor College of Medicine a Project Grant of $120,902 under the Vision Research program (CFDA 93.867) for research on the mechanisms of axoglial interactions at the paranodal junction (PNJ). The project, which commenced on April 15, 2026 and concludes on March 31, 2028, focuses on understanding the molecular composition and functional significance of the paranodal junction—the largest intercellular junction in vertebrates that anchors myelin sheaths to axons in the central nervous system. The research addresses critical knowledge gaps regarding how disrupted paranodes contribute to neurological and psychiatric disorders, axonal injury, regeneration, and aging processes. To advance this field, the project will develop and implement a reliable, medium-throughput pipeline for novel protein discovery at axoglial junctions by combining proximity-biotinylation-based subdomain proteomic profiling, CRISPR/Cas9-based genome editing, and cell type-specific adeno-associated virus (AAV) delivery systems. The research will utilize paranodal scaffolding protein ankyrin G as a molecular entry point to systematically dissect paranodal junction architecture and identify previously unknown proteins. The deliverables will include proteomic datasets, validated antibodies for paranodal proteins, and in vivo functional analyses to enhance understanding of axon-glia interactions and support reproducible scientific research in this understudied area of visual and neurological neuroscience.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $120.9k | 4/13/26 |