Project Grant R01EY036139
- This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides funding of $294,662 to Proteris Biotech, Inc. to support research on using the protein Clusterin (CLU) to treat ocular surface disease and dry eye. The project aims to determine whether CLU can protect the ocular surface epithelia from damage and also have an anti-inflammatory effect in dry eye disease. Recombinant human CLU will be tested for efficacy in a mouse...
- Federal Project Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded $451,000 to The Regents of the University of California, San Francisco on April 1, 2026, for a two-year research project concluding March 31, 2028. This project delivers advanced diagnostic research services through phage immunoprecipitation sequencing (PHIP-SEQ) analysis to identify autoantibodies associated with Sjögren's disease, particularly as it manifests as dry...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded $984,000 to The Regents of the University of California, San Francisco under the Vision Research program (CFDA 93.867) on September 30, 2025, for a planning and feasibility study on decentralized dry eye disease (DED) clinical trials. This R34 award, extending through September 29, 2027, will produce three primary deliverables: (1) development of a remote trial design framework enabling decentralized recruitment and study of...
- This Project Grant award for $383,000 from the National Eye Institute (CFDA 93.867 - Vision Research) aims to identify social determinants of health (SDOH) indicators associated with disparities in the diagnosis, management, and prognosis of dry eye disease. The project will leverage electronic health record data from a single-center and multi-center (Sight Outcomes Research Collaborative) datasets to build prognostic models that account for individual and structural barriers to accessing eye...
- Federal Grant Award Summary The National Eye Institute (Vision Research program, CFDA 93.867) awarded Icahn School of Medicine at Mount Sinai a $1,488,864 Project Grant effective September 1, 2025 through June 30, 2028 to conduct research on the epigenetic regulation of the meibomian gland in homeostasis and aging. The research aims to delineate epigenetic mechanisms controlling meibomian gland homeostasis and dysregulated in aging, with the ultimate goal of developing therapeutic...
- The National Eye Institute (NEI) awarded a $412,285 Project Grant under the Vision Research program (CFDA 93.867) to Oregon Health & Science University (OHSU) to validate an advanced transepithelial corneal collagen crosslinking (CXL) technology. The goal is to develop a more effective CXL procedure that can strengthen the cornea without requiring removal of the surface epithelium, which often leads to complications. The key products and services to be delivered include: Constructing an...
- Federal Grant Award Summary Augusta University Research Institute, Inc. received a $495,229 Project Grant from the National Eye Institute under the Vision Research program (CFDA 93.867) beginning April 1, 2026 and concluding February 28, 2029. The primary deliverables include the development of molecular-based diagnostic subtypes for dry eye disease (DED) through advanced proteomic analysis and machine learning classification. The project will employ high-resolution liquid...
- Federal Grant Award Summary Award Details: The National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), awarded Michigan State University $869,589 for a three-year project period (May 1, 2025 – April 30, 2028) to develop and validate a new animal model for studying evaporative dry eye disease (EDED). Research Products and Services: This project will establish EDED pathogenesis research capabilities through characterization of AWAT2 knockout (KO) mice, which...
- Federal Grant Award Summary Proteris Biotech, Inc. received a $321,904 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) effective August 1, 2025, through July 31, 2026. The award funds Phase I development of Clusterin (CLU), a novel therapeutic targeting epitheliopathy in dry eye disease. The company will conduct early-stage development activities at its Boston incubator facility, including non-Good Manufacturing Practice (GMP) stability...
- The National Eye Institute (NEI) has awarded a $356,485 Project Grant to Stellular Bio, Inc. under the NEI's Vision Research federal grant program (CFDA 93.867) to support the scale-up and manufacturing of STLR-201, an off-the-shelf regenerative therapeutic for Sjögren's syndrome-related dry eye disease (SSDE). STLR-201 is a platelet and stem cell-based product that promotes corneal epithelial cell proliferation and improves corneal barrier integrity, addressing the critical unmet need for a...
ROLES OF CASR IN OCULAR SURFACE HEALTH AND DISEASE - ABSTRACT DRY EYE DISEASE (DED) IS A MAJOR HEALTH PROBLEM. REDUCED OCULAR SURFACE HYDRATION IS A KEY PATHOLOGY IN DED, WHICH CAUSES SYMPTOMS AND CAN LEAD TO OCULAR SURFACE INFLAMMATION AND DAMAGE. CURRENT FDA- APPROVED TREATMENTS FOR DED INCLUDE ARTIFICIAL TEARS AND ANTI-INFLAMMATORY AGENTS THAT HAVE VARIABLE AND LIMITED EFFICACY. HERE WE PROPOSE A NOVEL TARGET FOR TREATMENT OF DED. THE TARGET IS THE EXTRACELLULAR CA2+-SENSING RECEPTOR (CASR) THAT HAS WELL-KNOWN MODULATORY EFFECTS ON EPITHELIAL ION TRANSPORT IN VARIOUS TISSUES SUCH AS INTESTINE AND KIDNEY. WE FOUND PROMINENT CASR EXPRESSION IN MOUSE AND HUMAN CORNEAL AND CONJUNCTIVAL EPITHELIAL CELLS. CASR ACTIVATION IN THE OCULAR SURFACE REDUCED CFTR-MEDIATED CL- SECRETION, CONFIRMING KEY ROLES OF CASR OCULAR SURFACE ION TRANSPORT. IMPORTANTLY, WE FOUND THAT CASR INHIBITION BY NPS-2143 STIMULATES CFTR-MEDIATED CL- SECRETION IN THE OCULAR SURFACE AND INCREASES TEAR FLUID VOLUME IN MICE BY ~100%. HERE WE WILL PERFORM KEY TRANSLATIONAL STUDIES FOR CASR INHIBITORS, BY TESTING THEM IN CLINICALLY RELEVANT ANIMAL AND HUMAN CELL MODELS OF DED TO ADVANCE THEM TOWARDS CLINICAL TESTING (AIM 1). WE WILL ALSO STUDY THE ROLES AND MECHANISMS OF CASR EFFECT IN OCULAR SURFACE ION TRANSPORT AND HEALTH (AIM 2). THE PROPOSED STUDIES CAN POTENTIALLY LEAD TO CLINICAL TESTING OF CASR INHIBITORS FOR DED IN THE VERY NEAR FUTURE. BY IDENTIFYING A NOVEL TREATMENT, THESE STUDIES CAN ULTIMATELY REDUCE DED MORBIDITY. LASTLY, BY IDENTIFYING ROLES AND MECHANISMS OF CASR IN OCULAR SURFACE, THIS PROJECT CAN ALSO IDENTIFY NOVEL DISEASE MECHANISMS FOR DED.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $410.0k | 5/1/25 | ||
| Not listed | $0 | 3/7/25 | ||
| Not listed | $0 | 3/7/25 | ||
| Not listed | $396.2k | 4/25/24 | ||
| Not listed | $396.2k | 4/25/24 |