Project Grant R21EY034330

Award Date 9/1/23
Completion Date 8/31/25
Dollars Obligated $412K
Federal Grant Program
93.867
Assistance Type
Project Grant
Place of Performance
Oregon, USA
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  1. Constructing an oxygen-UV delivery system to enrich oxygen levels in the cornea during UV irradiation for CXL.
  2. Measuring oxygen concentration in the corneal stroma during CXL using fiber-optic oximetry to test the hypothesis that the advanced transepithelial approach ("CASEY CXL") allows greater oxygen penetration compared to standard epithelium-off CXL.
  3. Using optical coherence tomographic elastography to non-destructively measure and compare increases in corneal stiffness achieved with CASEY CXL versus standard CXL.

These ex vivo experiments on rabbit and human eye bank corneas will validate the CASEY CXL protocol, including the drug formulation, procedure steps, and oxygen-UV delivery device, to prepare for future clinical trials in human patients. The award period is from September 1, 2023 to August 31, 2025.

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