Project Grant R01DA064914
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the Research Foundation For Mental Hygiene, Inc. (operating through the New York State Psychiatric Institute) a Project Grant totaling $195,804 under the Drug Use and Addiction Research Programs (CFDA 93.279) for the period August 1, 2026 through July 31, 2031. This research project investigates the effects of cannabis on nicotine use patterns, specifically examining how cannabis influences electronic nicotine...
- This $149,766 Project Grant, awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) and issued to Virginia Commonwealth University on August 17, 2026, supports research investigating the molecular mechanisms and behavioral outcomes of LYNX1 allosteric modulation of α3β4-nicotinic acetylcholine receptors in the context of nicotine use disorder. The research addresses two critical unresolved questions: (1) the binding site and...
- Federal Grant Award Summary Virginia Commonwealth University received a $1.397 million Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded September 1, 2025, with completion targeted for May 31, 2030. The grant supports the development of novel mu opioid receptor (MOR) modulators designed to counteract the effects of synthetic opioids, including fentanyl and other super-agonists driving the current opioid...
- Federal Grant Award Summary Oregon Health & Science University received a $905,044 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective May 1, 2026 through April 30, 2028. This mixed-methods research study will examine current practices and barriers related to electronic nicotine delivery systems (ENDS) use assessment and cessation assistance in primary care settings across 22 clinics serving over 154,000...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded $142,003 to the University of California Irvine on October 9, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the interaction between nicotine and GPR3 (G-protein coupled receptor 3) across gene expression, cellular activity, and withdrawal mechanisms. This three-year project, concluding September 30, 2028, addresses a critical public health gap by exploring GPR3 as an...
- Federal Grant Award Summary West Virginia University received a $931,766 Project Grant from the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279) effective August 1, 2025, through July 31, 2028. The project, "Evaluation of Dependence and Nicotine Replacement Therapy-Supported Cessation Efforts Among Regular Electronic Cigarette Users," addresses a critical gap in research regarding electronic cigarette (e-cigarette) dependence and...
- Virginia Commonwealth University received a $426,938 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective June 15, 2026, with a completion date of May 31, 2028. The grant supports research investigating whether Astrocyte Elevated Gene-1 (AEG-1), a novel transcriptional regulator protein, functions as an endogenous anti-opioid system. The research addresses the critical gap in understanding mu-opioid...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded a $734,188 Project Grant to the University of California, San Diego, effective July 15, 2026, through April 30, 2031, under the Drug Use and Addiction Research Programs (CFDA 93.279). This research initiative investigates sex differences in cannabis withdrawal mechanisms and recovery of neuropsychological and behavioral functioning in emerging adults (ages 18-25) with heavy cannabis use. The project will recruit...
- Federal Project Grant Award Summary George Mason University received a $710,029 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) awarded May 15, 2026, with completion targeted for February 28, 2031. The grant funds a research initiative examining how HIV infection and chronic nicotine exposure interact to promote CD4 T cell neuroinvasion and central nervous system (CNS) reservoir seeding in people living with HIV...
- Federal Cooperative Agreement Summary Award Overview Virginia Commonwealth University (VCU) received a $2.31 million Cooperative Agreement from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded September 15, 2025, with completion targeted for August 31, 2027. This collaborative project between VCU and Vivozon Inc. aims to establish preliminary safety and early efficacy data for VVZ-2471, a novel 5-HT2A and mGluR5 receptor...
Virginia Commonwealth University received a $591,405 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective July 15, 2026 through April 30, 2031. The award supports research to identify and characterize non-nicotine compounds in electronic nicotine delivery systems (ENDS) that contribute to abuse liability through functional activity at nicotinic acetylcholine receptor subtypes. The project deliverables include high-throughput screening (HTS) methods to comprehensively identify and characterize pharmacologically active non-nicotine compounds in ENDS liquids, and development of a novel inhalation-only preclinical ENDS exposure model to demonstrate the relevance of identified active compounds to tobacco product abuse liability. The research explicitly incorporates sex as a biological variable to investigate whether differences exist in how males and females experience ENDS-related effects and withdrawal, addressing a critical gap in understanding nicotine use disorder across populations. By systematically characterizing interactions between ENDS constituents and abuse-liability-relevant receptor subtypes, this project directly supports NIDA's mission to develop evidence-based knowledge for prevention, diagnosis, and treatment of substance use disorders, with particular attention to the emerging public health threat of ENDS products among youth and young adults.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $591.4k | 7/6/26 |