Project Grant R01ES037603
- Federal Grant Award Summary This Project Grant, awarded on April 23, 2026, by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), provides $1.40 million in funding to Michigan State University's Henry Ford Health + Michigan State University Health Sciences partnership through April 22, 2029. The award supports research investigating the mechanisms of lung toxicity resulting from skin exposure to vesicating agents,...
- Federal Project Grant Award Summary The University of Virginia received a $1.7M project grant from the Defense Health Agency (DHA) under the Military Medical Research and Development program (CFDA 12.420) to conduct research on preserving lung integrity and harnessing inflammation to treat burn-induced inhalation injury. The three-year award, which commenced May 1, 2026, and concludes April 30, 2029, supports hypothesis-driven biomedical research designed to develop innovative medical...
- Federal Grant Award Summary The University of Virginia received a $2.16 million Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2029. This award supports fundamental biomedical research investigating the mechanisms regulating inflammatory fibroblasts in wound healing. The project addresses a critical gap in understanding immune-stromal crosstalk...
- Federal Project Grant Award Summary The University of Alabama at Birmingham (UAB) received a $1.341 million Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective September 1, 2025, through August 31, 2028. The award funds a three-year research initiative investigating the mechanisms of delayed lung injury following exposure to trivalent arsenic chemical agents, including Lewisite, phenyl...
- Federal Grant Award Summary The University of Virginia received $806,901 in Project Grant funding from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), with an award date of August 1, 2025, and completion date of May 31, 2030. This research project investigates oxidation-specific epitope (OSE) immunoglobulin A (IgA) antibodies in idiopathic pulmonary fibrosis (IPF), a progressive lung disease with poorly understood...
- Federal Project Grant Award Summary The University of Virginia received a $644,997 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 21, 2025, with a completion date of May 31, 2030. This award supports research to identify and validate proteomic biomarkers predictive of pulmonary fibrosis progression and survival outcomes in idiopathic pulmonary fibrosis (IPF) patients. The project...
- Federal Grant Award Summary The University of Virginia received a $797,196 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded May 2, 2025, with completion scheduled for March 31, 2030. This research project investigates mechanosensing mechanisms at the intestinal surface, specifically focusing on how epithelial cell microvilli sense and respond to mechanical and chemical stimuli. The...
- Federal Grant Award Summary The University of Virginia received a $415,171 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 15, 2026, through February 28, 2031. This award funds a Maximizing Investigators' Research Award (MIRA) focused on developing the first three-dimensional hydrogel cell culture platform with photopatterned spatiotemporal control of viscoelasticity and...
- Federal Project Grant Award Summary The University of Virginia received a $353,430 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to support fundamental research into the regulation of ceramide-1-phosphate (C1P) metabolism in cell signaling networks. The research, scheduled for performance in Virginia from September 15, 2025 through July 31, 2029, investigates how C1P, a bioactive...
- Federal Grant Award Summary The University of Virginia received a $801,060 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective June 1, 2025 through March 31, 2030. This award supports the development and application of designer nanodiscs—next-generation molecular tools designed to advance the characterization and study of membrane proteins. The research focuses on overcoming limitations...
The University of Virginia received a $1.46 million Project Grant from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), awarded on April 14, 2026, with a three-year performance period concluding April 13, 2029. The project, titled "Preserving Lung Integrity and Harnessing Inflammation to Treat Vesicant-Induced Lung Injury," focuses on developing therapeutic approaches to mitigate lung injury caused by exposure to vesicant agents such as sulfur mustard and nitrogen mustard. The research investigates the role of MG53 (a vital protein component in cell membrane repair) in both facilitating tissue repair and limiting excessive inflammatory responses in lung epithelial cells and macrophages. The funded research aims to translate basic scientific findings regarding MG53 into potential therapeutic interventions that address both the acute phase of vesicant-induced lung injury and the inflammatory component of fibrotic remodeling. Specifically, the project will examine the physiological role and molecular mechanisms of MG53 in tissue repair and inflammation, with the ultimate goal of developing countermeasures to protect lung function against chemical and environmental insults. The work addresses a critical gap in treatment options for individuals exposed to vesicant agents by targeting dual pathways—membrane repair and inflammation modulation—through the application of recombinant human MG53 protein.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.5m | 4/13/26 |