Project Grant R01ES037611
- This Project Grant award from the Department of Health and Human Services National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) is focused on defining the molecular target of arsine gas-induced acute kidney injury and associated morbidity. The $222,750 award, provided from June 2025 to May 2027, supports research by the University of Alabama at Birmingham (UAB) to investigate the pathogenic molecular mechanisms underlying arsine gas-induced hemolysis...
- This Project Grant award, valued at $646,476.00, was provided by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health federal grant program (CFDA 93.113). The overarching goal of the research is to understand how environmental chemicals, such as inorganic arsenic, trigger deregulation of the epigenome that can resist epigenetic reprogramming in germ cells and become heritable. The award supports a study leveraging a model of germ cell reprogramming based...
- This federal Project Grant award, provided by the Department of Health and Human Services National Institutes of Health under the Trans-NIH Research Support program (CFDA 93.310), funds research to investigate mast cell activation as a common mechanism of pulmonary toxicity caused by chemical threat agents. The $1,395,741 award to the University of Colorado-Denver, effective September 1, 2025 through August 31, 2028, will support two specific aims. The research aims to confirm the in vivo...
- This $607,952 Project Grant award was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant supports research at the University of Pittsburgh to investigate indole metabolites as novel danger signals that activate regulated cell death pathways in lung epithelial cells, which may contribute to the pathogenesis of acute respiratory distress syndrome (ARDS). The key research objectives include...
- This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) Federal Grant Program provides $379,504 to the University System of New Hampshire's Keene State College to conduct research on the tissue-specific development of toxicity in response to transgenerational chronic arsenic exposures. The key objectives are to: (1) detect tissue-specific uptake of arsenic in response to transgenerational chronic exposure; (2)...
- This Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) provides $235,500 to Rutgers, The State University of New Jersey to conduct research on reducing chlorine-induced lung toxicity through the inhibition of macrophage activation. The research aims to develop medical countermeasures to mitigate the severe respiratory complications that can result from exposure to chlorine, a reactive gas that has been used as a chemical warfare...
- The University of Illinois was awarded a $108,512 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health federal grant program (CFDA 93.113). The grant, titled "LIPID-BASED INTERVENTIONS TO MITIGATE THE IMPACT OF ARSENIC ON MICROGLIAL FUNCTION AND NEUROBEHAVIOR", will fund research to investigate how the essential fatty acid docosahexaenoic acid (DHA) can protect against the neurobehavioral impacts of arsenic exposure. The...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under CFDA Program 93.837 Cardiovascular Diseases Research, is focused on studying the role of indole metabolites as danger signals in the pathogenesis of acute respiratory distress syndrome (ARDS). The $688,163 award to the University of Pittsburgh covers the period from Sep 1, 2025 to May 31, 2029. The research aims to investigate how microbial-derived indole metabolites activate regulated cell death...
- The Project Grant award R56ES034423 from the Department of Health and Human Services National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) provides $445,500 to the University of Alabama at Birmingham (UAB) to study the role of extracellular vesicles (EVs) and exosomes as mediators of injury from inhaled exposures to toxic chemicals such as sulfur mustard and chlorine. The project aims to: (A) characterize EVs/exosomes derived from the bronchoalveolar lavage fluid...
- This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $462,501 to The Regents of the University of Colorado, doing business as University of Colorado-Denver, to conduct research on mast cell activation as a common mechanism of pulmonary toxicity from chemical threat agents. The two-year project aims to examine how activation of mast cells contributes to lung inflammation and injury caused by exposure to various...
This $1,341,000 Project Grant was awarded by the Department of Health and Human Services National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310). The grant will fund research at the University of Alabama at Birmingham (UAB) to investigate the mechanisms of delayed lung injury following single exposures to trivalent arsenic chemical agents such as Lewisite, phenyl arsenic oxide, and arsenic trioxide. The research aims to determine how these exposures trigger the release of self-double-stranded DNA in the form of NETs, which activate IRF7 in airway epithelial cells, leading to the transcription of type I interferons and contributing to airway fibrogenesis and persistent inflammation. This 3-year research project, with a start date of September 1, 2025, will provide critical insights into the pathophysiology of delayed lung disorders associated with acute trivalent arsenic exposures.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.3m | 8/28/25 |