Project Grant R35GM156345

Award Date 5/2/25
Completion Date 3/31/30
Dollars Obligated $399K
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Virginia, USA
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This federal Project Grant award of $440,454 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) will support a research project focused on epithelial cell mechanobiology in mechanically heterogeneous microenvironments. The primary objectives are to study how epithelial cells sense and respond to extracellular wounds, whether epithelial migration can occur with lower forces by modifying extracellular matrix...
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This Project Grant award, valued at $398,598.00 and effective from May 2, 2025 to March 31, 2030, was issued by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859).

The award supports research to investigate the molecular machineries and physiological consequences of mechanochemical sensing in epithelial cell microvilli, which play critical roles in environmental sensing and response. The research aims to provide conceptual advances in understanding microvilli-mediated signaling in epithelial physiology and its implications for conditions like allergic and autoimmune diseases. The work will be conducted by the Rector & Visitors of the University of Virginia, leveraging advanced in vivo imaging and systems biology approaches to study these fundamental mechanisms across different organs and scales.

Generated 5/13/25, 5:26 AM