This federal Project Grant award of $440,454 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) will support a research project focused on epithelial cell mechanobiology in mechanically heterogeneous microenvironments. The primary objectives are to study how epithelial cells sense and respond to extracellular wounds, whether epithelial migration can occur with lower forces by modifying extracellular matrix...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support a $361,054 research project at Virginia Commonwealth University (VCU) from July 1, 2024 to May 31, 2029. The project aims to investigate how mechanical cues in the cellular microenvironment activate leader cells and drive directional collective cell migration, which is essential for processes like wound healing and cancer...
This federal Project Grant award, valued at $733,870.00 and effective from September 1, 2024 to August 31, 2029, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The objective of this award is to advance the fundamental understanding of cell signaling through quantitative analysis of membrane protein interactions, with a focus on receptor tyrosine kinases (RTKs) and G protein-coupled receptors...
This $387,662 federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research at Duke University to elucidate the molecular mechanisms of cellular mechanosensitivity. The project aims to develop biosensors to study how protein phosphorylation affects the mechanical state of linker proteins, identify key mediators of mechanosensitivity, and evaluate the role of these...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $349,681.00 in funding to the University of Maryland, College Park to develop novel force nanoprobes for visualizing and quantifying intracellular forces in living cells. The goal is to create a detailed map of the mechanical forces acting on the genome, which could provide critical insights into the mechanisms of mechanical...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), provides $372,100 to the University of Wisconsin System to develop novel "mechanoimaging" technologies that can measure and program piconewton-scale receptor forces in viscoelastic materials. The key objectives are to: 1) Quantify the magnitude and distribution of forces that cells, such as fibroblasts, cancer cells, and...
This $1,188,963 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to explore how the enzyme PRMT5 regulates cellular functions through substrate arginine methylation. The project aims to identify how PRMT5 substrates are recruited for methylation and the downstream biochemical effects on processes like mRNA binding, protein complex formation, and mRNA splicing. This research is...
This federal Project Grant award of $387,104 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development of platform technologies for constructing voxelated 3D tissues with molecular architecture-encoded modular biomaterials to understand and control stem cell function. The key products and services to be delivered under this 5-year grant include: Developing modular bottlebrush gels to understand and...
This $627,797 five-year Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training federal grant program (CFDA 93.859). The goal of the research program is to delineate the mechanisms by which membrane-associated protein complexes shape tissue form and function, with a focus on how their dysfunction leads to human diseases. The research approach combines genetic screens, transgenesis, live imaging in C....
This federal Project Grant award of $852,726, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research that aims to elucidate the mechanisms regulating sub-cellular organization and the significance of this organization to organelle and cell function. The award will leverage advanced quantitative microscopy methods developed by the research team to visualize the spatial organization of cells...