Project Grant R35GM162024
- Federal Project Grant Award Summary The University of Virginia received a $425,145 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 1, 2026, through February 28, 2031. This award funds the development of integrated microscopy and image processing technologies to enable non-invasive, long-term three-dimensional (3D) fluorescence imaging and single-cell morphometry of...
- Federal Grant Award Summary The University of Virginia received a $353,430 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded on September 15, 2025, with a completion date of July 31, 2029. This award funds fundamental biomedical research investigating the regulation of ceramide-1-phosphate (C1P) metabolism in cellular signaling networks, specifically examining how C1P facilitates...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded the University of Virginia $444,125 under the Biomedical Research and Research Training program (CFDA 93.859) to conduct fundamental research on protein sorting and localization to cellular organelles. The project, which commenced August 1, 2025, and extends through June 30, 2030, will deliver scientific research outputs focused on elucidating the molecular mechanisms governing protein import and...
- Federal Project Grant Award Summary The University of Virginia received a $2.16 million Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2029. This award funds research to investigate the mechanisms regulating inflammatory fibroblasts in wound healing, with particular focus on understanding how immune-stromal cell interactions influence...
- Federal Grant Award Summary The University of Virginia received a $395,698 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded February 15, 2026, with a completion date of January 31, 2031. This award supports fundamental basic research investigating how the structural complexity of stem cell niches enables stem cell function during development and homeostasis. The research utilizes...
- Federal Grant Award Summary The University of Virginia received a $1,092,610 Project Grant award from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859), effective March 15, 2026 through February 28, 2030. The grant funds the development of an Impedance-Activated Recognition, Tracking, and Sorting (IARTS) system, a novel label-free technology platform designed to identify, monitor, and isolate individual cells based on...
- Federal Grant Award Summary The University of Virginia received a $400,530 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective June 1, 2025, through March 31, 2030. This award supports the development of advanced nanodisc technology platforms designed to investigate membrane protein-lipid interactions and their role in cellular signaling and physiology. The research will focus on...
- Federal Grant Award Summary The University of Virginia received a $444,125 Project Grant from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859), awarded March 1, 2026, with a completion date of February 28, 2031. This award supports fundamental research to elucidate the mechanisms of genome integrity maintenance, specifically investigating break-induced replication (BIR) at repetitive DNA sequences, with emphasis on...
- Federal Project Grant Award Summary The University of Virginia received a $426,360 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective July 1, 2025 through June 30, 2030. The Molecular Biophysics Training Grant (MBTG) program will provide comprehensive graduate training in biophysics to exceptional doctoral students from the School of Medicine, Graduate School of Arts and Sciences,...
- Federal Project Grant Award Summary The University of California, Davis received a $432,417 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded April 1, 2026, with completion targeted for January 31, 2031. This award supports investigator-initiated fundamental biomedical research examining the mechanisms by which extracellular matrix (ECM) mechanical properties regulate cellular...
The University of Virginia received a $415,171 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 15, 2026, with completion targeted for February 28, 2031. This Maximizing Investigators' Research Award (MIRA) funds the development and characterization of the first photopatterned hydrogel 3D cell culture platform capable of spatiotemporal control of viscoelasticity and stress relaxation. The research addresses a critical knowledge gap in mechanobiology by creating cell-instructive biomaterial systems that replicate the heterogeneous viscoelastic mechanics of native tissues during development, disease progression, and wound repair—properties that current 3D models fail to adequately replicate. The project deliverables span two integrated research themes. Theme 1 focuses on fabricating and validating hydrogels with phototunable dynamic covalent crosslinks and guest-host interactions that enable precise spatial and temporal control of viscoelasticity guided by tissue nanoindentation and rheology data. Theme 2 investigates immune-stromal cell mechanotransduction within these viscoelastic environments, specifically examining how macrophage-fibroblast interactions and mechanical signaling through YAP/TAZ and TRPV4 pathways are modulated by varying stress relaxation timescales. These investigations are designed to elucidate fundamental mechanisms of mechanobiology while providing foundational knowledge for understanding fibroproliferative diseases and developing improved therapeutic interventions.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $415.2k | 3/12/26 |