Project Grant R35GM160121
- This $428,600 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports an investigation into how RNA-directed feedback loops coordinate wound healing and regeneration. The research project aims to understand the conserved developmental pathways and heterochronic genes that regulate cell migration, fate, and timing during normal adult wound repair and regeneration,...
- The federal Project Grant award of $726,452 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to model intra- and inter-cellular networks involved in TRPC6-dependent cardiac fibrosis. The award aims to leverage computational methods and multi-scale experiments to better understand how TRPC6 signaling drives myofibroblast transformation and fibrosis in response to cardiac and dermal wounds. The research will be conducted by the...
- This $249,000 project grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to elucidate the epigenetic regulation of the extracellular matrix and virus-induced fibroblast activation. The research project, which will be conducted at Tufts University over a 3-year period from September 15, 2025 to September 14, 2028, seeks to advance the understanding of the molecular mechanisms...
- This federal Project Grant award in the amount of $311,770.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award is supporting research at Vanderbilt University to investigate the mechanisms of tissue repair, with a focus on understanding epithelial repair and basement membrane repair. The research aims to advance knowledge of how cells coordinate migration, proliferation, and...
- This $350,000 National Science Foundation project grant supports research at the University of Virginia from October 1, 2022 to September 30, 2025 under the NSF Engineering program (CFDA 47.041). The research aims to advance understanding of the effects of microgravity on wound healing processes by leveraging a sensor-integrated 3D tissue culture model. Specifically, the project will explore dynamic changes in gene and protein expression, endothelial network formation, and extracellular matrix...
- This federal Project Grant award of $400,000 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research by Baylor College of Medicine to develop and optimize bioengineered polymers with tunable properties to modulate inflammatory responses in the wound microenvironment. The goal is to enhance tissue repair and regeneration across different wound types, particularly in chronic wounds where...
- This $398,598 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support research on mechanosensing mechanisms in intestinal epithelial cells. The principal investigator will use super-resolution functional imaging and in vivo interactomic approaches to identify conserved molecular machineries that drive mechanochemical sensing in epithelial microvilli, investigate physiological...
- This Project Grant award, valued at $451,000.00 and funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to determine the physiological nutrients and metabolic pathways required for fibroblast extracellular matrix (ECM) synthesis during tissue repair. The research program, to be conducted at the University of Chicago from September 1, 2025 to August 31, 2030, aims to address the central...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop a hyperstable and bioactive FGF1-FGF2 dimer formulation for effective healing of diabetic skin wounds. The $435,226 award to the University of Arkansas will fund research activities across three key objectives: Designing a hyperstable and bioactive FGF1-FGF2 dimer and its variants, Developing injectable anionic...
- This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $502,940 to James Madison University (JMU) is funding research to investigate the molecular mechanisms underlying the relationship between tissue fibrosis and angiogenesis following injury. The research aims to elucidate how the sphingosine 1-phosphate (S1P) and cyclooxygenase-2 (COX-2) pathways mediate the crosstalk between these two critical tissue repair and regeneration processes. The...
This Project Grant award, valued at $2,157,780.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award will fund research focused on understanding the role and regulation of inflammatory fibroblasts in wound healing, a critical aspect of human health. The research aims to investigate how immune-stromal cell crosstalk contributes to wound healing, as well as whether fibroblasts can perpetuate chronic inflammation. The project will be conducted by the Rector & Visitors of the University of Virginia, a prominent public research university, over the period of September 1, 2025 to August 31, 2029. The findings from this research have the potential to advance the understanding of dysregulated wound healing and its contribution to fibrotic disorders, which account for a significant percentage of deaths in the developed world.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.2m | 8/5/25 |