This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will provide $398,598 over a period of 5 years to support research on mechanosensing mechanisms in epithelial cell microvilli. The research aims to identify the molecular machineries that drive mechanochemical sensing in epithelial microvilli, understand the physiological consequences of microvillar signaling, and investigate how the in vivo...
This $186,250 Project Grant award from the National Cancer Institute's Cancer Biology Research program (CFDA 93.396) will support the development and characterization of membrane-sensitive fluorescent probes to measure the nano-scale lipid environments, or "paralipidomes", surrounding membrane proteins in living cells. The research team at the University of Virginia will employ a combined simulation-experiment approach to calibrate various fluorescent sensors to specific membrane...
The University of Virginia received a $387,104 Project Grant from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) to develop platform technologies for constructing 3D voxelated tissues with molecular architecture-encoded modular biomaterials. The objectives are to: 1) Develop modular bottlebrush gels to understand and control cell-matrix interactions by independently encoding stiffness, strain-stiffening, relaxation time,...
The National Institute of General Medical Sciences (NIGMS) awarded a $218,622 Project Grant to Vitan-Biotech LLC on September 22, 2023 under the Biomedical Research and Research Training program (CFDA 93.859). The grant will fund the development of an integrated pipeline to rapidly discover and characterize selective, high-affinity nanobodies against defined G protein-coupled receptors (GPCRs) that are important for neurological disorders like schizophrenia, pain, Parkinson's, Alzheimer's, and...
The National Institute of General Medical Sciences (NIGMS) awarded a $356,462.00 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of California, Irvine (UC Irvine) to develop new computational tools for analyzing cell-cell communication using spatial transcriptomic data. The key products and services to be delivered under this 4-year award include: Improved methods to use single-cell RNA sequencing data to enhance coverage of genes associated with...
The National Institute of General Medical Sciences (NIGMS) awarded a $382,136 Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) to the University of Maryland, College Park. The 5-year grant, effective May 1, 2025 through March 31, 2030, supports research to define engineering principles for designing programmable bioengineered multicellular structures (probioms) in prokaryotic cells. The goal is to develop a framework for engineering probiotic-based...
This $372,100 Project Grant was awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant, effective from February 1, 2025 to January 31, 2030, supports the development of novel "mechanoimaging" technologies that convert receptor-level forces into visible light fluorescence. The goal is to quantify and control receptor-level forces in viscoelastic materials, which is a fundamental...
This $456,977 project grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to elucidate the membrane properties regulating antimicrobial peptide binding to bacterial outer membrane vesicles (OMVs). The research will leverage innovative approaches to study protein-lipid interactions at the single-vesicle and subpopulation levels, in order to uncover the specific OMV characteristics that influence...
This $379,131 federal Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to accelerate the development of macromolecule-based therapeutics. The primary objectives are to: 1) Establish rapid characterization methods to assess the conformation and dynamics of disordered peptides and peptidomimetics, 2) Develop predictive algorithms to identify sequence spaces favoring desired...
The National Institute of General Medical Sciences (NIGMS) awarded a $917,454 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Integral Molecular Inc. to develop a novel Membrane Proteome Array (MPA) technology for biotherapeutic specificity screening. The MPA represents 93% of the human extracellular proteome expressed in live cells, providing a more predictive and sensitive approach for profiling off-target binding of monoclonal antibodies and other...