Project Grant R01DK147092
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $795,317 to the Research Institute At Nationwide Children's Hospital on August 19, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the roles of RNase3, RNase6, and ribonuclease inhibitor in bacterial urinary tract infection. The research uses engineered transgenic mice to determine how RNase3 and RNase6, phagocyte-derived antimicrobial peptides in the...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Cincinnati Children's Hospital Medical Center $750,253 on July 27, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to engineer human kidney organoids with functional collecting duct systems. The project, titled "Engineering Structure and Function of Human Kidney Organoids," addresses critical limitations in kidney organoid research by developing an...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pittsburgh $148,155 on August 17, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to support a five-year project examining the role of PIEZO1, a mechanosensitive cation channel, in renal function and fibrosis. The research investigates PIEZO1 regulation and activity in the distal nephron through two primary aims. Aim 1 examines how aldosterone and...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $517,589 to the Research Institute At Nationwide Children's Hospital on May 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to fund Project Grant R01DK142085. The award supports research to characterize the structure and function of regulatory complexes controlling erythrocyte hydration and red blood cell volume homeostasis. The project combines cellular,...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pennsylvania $691,758 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate DCLK1 isoform switching and its role in proximal tubule injury during kidney disease progression. The award funds basic research to understand how DCLK1 regulates inflammation and DNA damage response pathways in injured proximal tubule cells, which...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Children's Hospital of Philadelphia $796,742 on February 6, 2026, to develop a urinary peptide panel for risk stratification in patients with spina bifida under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The project addresses identification of patients whose neurogenic bladder dysfunction places their upper urinary tract at risk of chronic kidney disease progression,...
- The National Institute of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health within the Department of Health and Human Services, awarded Children's Research Institute $156,814 on August 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to support Project Grant K08DK149197. The award funds research defining immunomodulatory mechanisms in autosomal recessive polycystic kidney disease (ARPKD), a severe...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $713,227 to the University of Wisconsin–Madison on August 20, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847, Project Grant R01DK146259). The award funds research on the role of A-fiber mechanosensitive neurons in bladder function and urologic disease phenotypes, with focus on urologic chronic pelvic pain syndrome (UCPPS). The research team has developed new tools for...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Beth Israel Deaconess Medical Center $1.552 million on September 9, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to map mechanosensory circuits from the bladder to Barrington's nucleus. The recipient will use immediate early gene activity, RNA sequencing, fiber photometry, and cellular-resolution calcium imaging to identify central nervous system nuclei and cell...
- The National Institute of Diabetes and Digestive and Kidney Diseases, an institute within the Department of Health and Human Services National Institutes of Health, awarded the Regents of the University of Michigan $690,854 on February 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds research to identify molecular and genetic mechanisms that determine and maintain kidney epithelial cell states in normal physiology and in...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded the Research Institute at Nationwide Children's Hospital $789,682 on August 25, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds research into the mechanisms by which the renal urothelium senses and responds to urinary tract obstruction and mitigates obstructive nephropathy. The project investigates how the renal urothelium undergoes remodeling during urinary tract obstruction, marked by proliferation of keratin 5 cells and differentiation of uroplakin cells that form tight junctions and enhance barrier impermeability. The research identifies the mechanoreceptor PIEZO1 as a key transducer of mechanical stress into urothelial remodeling and examines PPARG as a master regulator of uroplakin differentiation. The work aims to define cellular and molecular mechanisms and determine whether restoring uroplakin-mediated barrier function could mitigate kidney injury and preserve renal function in patients with obstructive nephropathy. Work is performed in Columbus, Ohio. The period of performance extends from the award date through April 30, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $789.7k | 8/25/26 |