Project Grant R01DK144418
- Federal Grant Award Summary Cincinnati Children's Hospital Medical Center received a $240,978 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded September 1, 2025, with completion expected by August 31, 2027. This research project will deliver transcriptional, regulatory, and spatial analysis of kidney development changes during mid to late...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the Research Institute at Nationwide Children's Hospital $789,682 on August 25, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds research into the mechanisms by which the renal urothelium senses and responds to urinary tract obstruction and mitigates obstructive nephropathy. The project investigates how the renal urothelium undergoes remodeling during...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Children's Hospital of Philadelphia Research Institute $1.868 million on June 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct integrative proteomics, metabolomics, and genomics analysis identifying mechanistic pathways of adverse outcomes in pediatric chronic kidney disease. The research leverages stored biosamples and existing data from over 1,100...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Washington University $388,750 on April 23, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the structural and functional mechanisms of podocin in glomerular membrane organization and kidney disease. The research applies detergent-free, vesicle-based cryo-electron microscopy to determine the full-length structure of podocin at near-atomic resolution...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Massachusetts General Hospital $251,626 on April 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct basic research on c-kit receptor signaling in kidney collecting duct function. The research investigates the role of c-kit receptor signaling in modulating collecting duct epithelial cell composition and function. The project uses c-kit "sash" mice...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the Veterans Medical Research Foundation of San Diego $383,098 on September 2, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The recipient will conduct research into kidney tubule dysfunction in APOL1-associated chronic kidney disease, with focus on developing and validating tubular biomarkers that capture kidney functions—nutrient reabsorption and toxin...
- The National Institute of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health within the Department of Health and Human Services, awarded Children's Research Institute $156,814 on August 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to support Project Grant K08DK149197. The award funds research defining immunomodulatory mechanisms in autosomal recessive polycystic kidney disease (ARPKD), a severe...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pennsylvania $691,758 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate DCLK1 isoform switching and its role in proximal tubule injury during kidney disease progression. The award funds basic research to understand how DCLK1 regulates inflammation and DNA damage response pathways in injured proximal tubule cells, which...
- The National Institute of Diabetes and Digestive and Kidney Diseases, an institute within the Department of Health and Human Services National Institutes of Health, awarded the Regents of the University of Michigan $690,854 on February 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds research to identify molecular and genetic mechanisms that determine and maintain kidney epithelial cell states in normal physiology and in...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Washington $192,763 on March 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), a Project Grant supporting basic and clinical biomedical research that improves understanding of disease mechanisms and leads to improved prevention, diagnosis, and treatment. The award funds a prospective nested cohort study investigating mechanisms of kidney...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded Cincinnati Children's Hospital Medical Center $750,253 on July 27, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to engineer human kidney organoids with functional collecting duct systems. The project, titled "Engineering Structure and Function of Human Kidney Organoids," addresses critical limitations in kidney organoid research by developing an integrated platform that combines nephrogenic mesenchyme with ureteric bud progenitor cells. Current organoids lack collecting ducts and fail to establish drainage pathways analogous to in vivo nephron development. The research will investigate how Wnt and Notch signaling interactions coordinate nephron segmentation and fusion with collecting systems, with the goal of enhancing nephron connectivity and integration efficiency. The work supports basic biomedical research to improve understanding of kidney disease mechanisms, informing potential new therapeutic approaches for chronic kidney disease, which affects an estimated one in seven U.S. adults. Performance of work occurs in Cincinnati, Ohio, with a period of performance extending from the award date through April 30, 2031. The award is structured as a Project Grant, the standard assistance type for individual investigator-initiated research under the NIDDK extramural portfolio.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $750.3k | 7/27/26 |