Project Grant R01DK141592
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the Research Institute at Nationwide Children's Hospital $789,682 on August 25, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds research into the mechanisms by which the renal urothelium senses and responds to urinary tract obstruction and mitigates obstructive nephropathy. The project investigates how the renal urothelium undergoes remodeling during...
- The National Institute of Diabetes and Digestive and Kidney Diseases, a component of the Department of Health and Human Services National Institutes of Health, awarded $674,691 to the Trustees of Indiana University (doing business as Indiana University Indianapolis) on August 20, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds research investigating alternative splicing of uromodulin (AS-UMOD) as a protective mechanism against...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Research Foundation for the State University of New York $2,401,176 on September 9, 2025, to support research investigating polymicrobial interactions and within-host bacterial adaptation in catheter-associated urinary tract infections (CAUTI). The research examines how three species — Enterococcus faecalis, Proteus mirabilis, and Escherichia coli — interact to enhance biofilm formation on urinary catheters and...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $711,430 to the University of Pittsburgh on July 27, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of sex-specific microRNA regulation in acute kidney injury. The research examines how sex-differentially expressed microRNAs, particularly the mir-1792 cluster, protect tubular epithelial cells during acute kidney injury by repressing...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Cincinnati Children's Hospital Medical Center $750,253 on July 27, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to engineer human kidney organoids with functional collecting duct systems. The project, titled "Engineering Structure and Function of Human Kidney Organoids," addresses critical limitations in kidney organoid research by developing an...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Washington University $547,349 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the mechanisms of E. coli alpha-hemolysin toxicity to renal epithelium. The project, R01DK142175, examines how uropathogenic E. coli (UPEC) employs the secreted toxin alpha-hemolysin (HlYA) to damage kidney tissue during urinary tract infections,...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Regents of the University of California, San Francisco $193,747 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to support the Children's Urinary Tract Infection Evaluation (CUE) Study. Principal investigator Rachel Wattier, MD, MHS, a pediatric infectious diseases physician trained in clinical epidemiology and health system quality improvement, is...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Ann & Robert H Lurie Children's Hospital of Chicago $164,580 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847, Project Grant K08DK147611) to investigate immune-mediated mechanisms of tubulointerstitial injury in childhood nephrotic syndrome. The award funds basic research characterizing how dendritic cells and related inflammatory pathways contribute...
- Federal Project Grant Award Summary The University of Texas Health Science Center at Houston received a $226,253 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded September 1, 2025, with a completion date of August 31, 2027. The research project aims to elucidate the within-host and between-host adaptations that enable Staphylococcus aureus...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $713,227 to the University of Wisconsin–Madison on August 20, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847, Project Grant R01DK146259). The award funds research on the role of A-fiber mechanosensitive neurons in bladder function and urologic disease phenotypes, with focus on urologic chronic pelvic pain syndrome (UCPPS). The research team has developed new tools for...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded $795,317 to the Research Institute At Nationwide Children's Hospital on August 19, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the roles of RNase3, RNase6, and ribonuclease inhibitor in bacterial urinary tract infection. The research uses engineered transgenic mice to determine how RNase3 and RNase6, phagocyte-derived antimicrobial peptides in the human urinary tract, affect host susceptibility to UTI through antimicrobial and immunomodulatory effects. The work includes investigation of ribonuclease inhibitor's role in governing the antimicrobial activity of these RNases and examination of how inhibitor and PI3K/AKT signaling impact phagocyte UTI defenses. The studies aim to advance understanding of antimicrobial peptide function and regulation during UTI and support development of antimicrobial peptide-based therapeutic strategies for UTI prevention and treatment. The award period runs through May 31, 2031, with performance in Columbus, Ohio. The funding mechanism is a Project Grant, the standard NIH research award supporting basic and clinical research that improves understanding of disease mechanisms and leads to improved prevention, diagnosis, and treatment within NIDDK's priority areas.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $795.3k | 8/19/26 |