Project Grant R01DK148464
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pennsylvania $258,031 on May 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to employ long-read RNA sequencing to comprehensively characterize alternative splicing events in kidney tissue and their role in chronic kidney disease. The recipient will conduct bulk kidney tissue analysis to identify novel isoforms and compare isoform expression between...
- Federal Project Grant Award Summary The University of Pennsylvania received a $243,750 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 5, 2025, through September 4, 2027. This award supports investigator-initiated biomedical research examining the role of DCLK1 (doublecortin-like kinase 1) in regulating the DNA damage response within...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the Veterans Medical Research Foundation of San Diego $383,098 on September 2, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The recipient will conduct research into kidney tubule dysfunction in APOL1-associated chronic kidney disease, with focus on developing and validating tubular biomarkers that capture kidney functions—nutrient reabsorption and toxin...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pittsburgh $812,862 on June 12, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to identify novel biomarkers of early progressive kidney function decline in type 1 diabetes. The research will use urinary and plasma peptidomics—analysis of synthesized peptides and protein degradation fragments—to discover prognostic markers that predict diabetic...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pittsburgh $556,648 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of FAN1 protein in preventing chronic kidney disease progression following acute kidney injury. The research targets DNA damage response and mitochondrial dysfunction in kidney tubular epithelial cells. The project will test whether enhancing...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Children's Hospital of Philadelphia Research Institute $1.868 million on June 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct integrative proteomics, metabolomics, and genomics analysis identifying mechanistic pathways of adverse outcomes in pediatric chronic kidney disease. The research leverages stored biosamples and existing data from over 1,100...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Washington $192,763 on March 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), a Project Grant supporting basic and clinical biomedical research that improves understanding of disease mechanisms and leads to improved prevention, diagnosis, and treatment. The award funds a prospective nested cohort study investigating mechanisms of kidney...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pennsylvania $792,019 on May 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to phenotype and predict ultrafiltration intolerance and guide transitions from continuous to intermittent kidney replacement therapy. The award funds research addressing hemodynamic complications that arise when critical-care patients transition from continuous kidney...
- The National Institute of Diabetes and Digestive and Kidney Diseases, an institute within the Department of Health and Human Services National Institutes of Health, awarded the Regents of the University of Michigan $690,854 on February 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds research to identify molecular and genetic mechanisms that determine and maintain kidney epithelial cell states in normal physiology and in...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Vanderbilt University Medical Center $866,265 on May 13, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate non-canonical ephrin B2 receptor (EPHB2) signaling in acute kidney injury and its progression to chronic kidney disease. The research examines how EPHB2 and transforming growth factor beta signaling pathways contribute to kidney inflammation and...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pennsylvania $691,758 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate DCLK1 isoform switching and its role in proximal tubule injury during kidney disease progression. The award funds basic research to understand how DCLK1 regulates inflammation and DNA damage response pathways in injured proximal tubule cells, which accumulate during chronic kidney disease and aging. The research applies single-cell sequencing methods and novel algorithms to identify and characterize these maladaptive cells and their pro-inflammatory, pro-fibrotic signaling. The project examines how DCLK1 overexpression in injured proximal tubule cells drives disease progression through NFκB activation and whether targeting these pathways could limit kidney fibrosis and injury to neighboring healthy cells. The work builds on DCLK1's prior association with chronic kidney disease in genome-wide meta-analysis and its observed upregulation in animal disease models. Work is performed in Philadelphia, Pennsylvania, with a period of performance from September 1, 2026, through May 31, 2031. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $691.8k | 8/20/26 |