Project Grant K01DK146201
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pittsburgh $812,862 on June 12, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to identify novel biomarkers of early progressive kidney function decline in type 1 diabetes. The research will use urinary and plasma peptidomics—analysis of synthesized peptides and protein degradation fragments—to discover prognostic markers that predict diabetic...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the Research Institute at Nationwide Children's Hospital $789,682 on August 25, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds research into the mechanisms by which the renal urothelium senses and responds to urinary tract obstruction and mitigates obstructive nephropathy. The project investigates how the renal urothelium undergoes remodeling during...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pittsburgh $556,648 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of FAN1 protein in preventing chronic kidney disease progression following acute kidney injury. The research targets DNA damage response and mitochondrial dysfunction in kidney tubular epithelial cells. The project will test whether enhancing...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pennsylvania $691,758 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate DCLK1 isoform switching and its role in proximal tubule injury during kidney disease progression. The award funds basic research to understand how DCLK1 regulates inflammation and DNA damage response pathways in injured proximal tubule cells, which...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $711,430 to the University of Pittsburgh on July 27, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of sex-specific microRNA regulation in acute kidney injury. The research examines how sex-differentially expressed microRNAs, particularly the mir-1792 cluster, protect tubular epithelial cells during acute kidney injury by repressing...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Washington University $388,750 on April 23, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the structural and functional mechanisms of podocin in glomerular membrane organization and kidney disease. The research applies detergent-free, vesicle-based cryo-electron microscopy to determine the full-length structure of podocin at near-atomic resolution...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Virginia Commonwealth University $714,743 on August 13, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of PIEZO1 mechanosensitive ion channels in renal medullary telocytes as pressure sensors regulating blood pressure through exosome-mediated signaling. The research will elucidate mechanisms of pressure natriuresis—the process by which...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pittsburgh $698,501 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to identify gene-level interactions between host immunity and the intestinal microbiota that regulate inflammation in inflammatory bowel disease. The funded research combines microbiota analysis tools, host single-cell RNA sequencing, and machine learning methods to...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pittsburgh $380,808 on June 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop and test a pharmacist-led population health management intervention designed to optimize guideline-recommended medication therapy for individuals with chronic kidney disease. The research addresses medication therapy problems in nephrology care, where up to...
- The National Institute of Diabetes and Digestive and Kidney Diseases, an institute within the Department of Health and Human Services National Institutes of Health, awarded the Regents of the University of Michigan $690,854 on February 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds research to identify molecular and genetic mechanisms that determine and maintain kidney epithelial cell states in normal physiology and in...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pittsburgh $148,155 on August 17, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to support a five-year project examining the role of PIEZO1, a mechanosensitive cation channel, in renal function and fibrosis. The research investigates PIEZO1 regulation and activity in the distal nephron through two primary aims. Aim 1 examines how aldosterone and downstream signaling pathways regulate PIEZO1 expression and activity, using mice expressing tdTomato-tagged PIEZO1 assessed via RNAscope and immunofluorescent staining, isolated cortical collecting ducts for calcium influx and current measurements, and cell culture models to evaluate the mineralocorticoid receptor and NEDD4-2's involvement in PIEZO1 regulation. Aim 2 evaluates the protective role of tubular PIEZO1 against stretch-induced injury by subjecting mice with pantubular or distal nephron genetic knockout of PIEZO1 to unilateral ureteral obstruction, then analyzing fibrosis and injury through biochemical and histological methods, cell cycle arrest markers (KI-67 and phospho-histone H3 staining), and YAP transcriptional coactivator activation. These genetic models will be compared to animals receiving the non-specific mechanosensitive ion channel inhibitor GSMTX4. Work is performed in Pittsburgh, Pennsylvania, with a period of performance from August 17, 2026, through May 31, 2031. The award is classified as a Project Grant and carries assistance type designation accordingly.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $148.2k | 8/17/26 |