Project Grant R01DK143962
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $192,268 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Icahn School of Medicine at Mount Sinai (ISMMS) to assess the effects of proposed HIV cure strategies in the gut-associated lymphoid tissue. This 5-year award, starting on August 26, 2025, aims to investigate the impact of HIV cure approaches on the viral reservoir located in the gut, as a large proportion of the...
- The National Institute of Mental Health (NIMH) awarded a $3,613,504 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to the Icahn School of Medicine at Mount Sinai (ISMMS) on September 22, 2025. This 4-year grant aims to investigate the role of the NLRP3 inflammasome in HIV-induced neuroinflammation and its impact on HIV persistence in the central nervous system (CNS). The project has three key objectives: 1) Elucidate the link between HIV-1 infection and NLRP3...
- This Project Grant award from the Department of Health and Human Services' National Institutes of Health (CFDA 93.310 - Trans-NIH Research Support) provides $703,644 to the Icahn School of Medicine at Mount Sinai to investigate the drivers of accelerated aging in people living with HIV (PWH). The research aims to study the effects of HIV and antiretroviral therapy on epigenetic aging and clonal hematopoiesis, as well as examine the role of socio-behavioral factors and genetic predisposition in...
- This $1,554,672 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) aims to define the molecular mechanisms underlying gut inflammation and barrier dysfunction in people living with HIV. The grant supports research led by The Washington University in Missouri to establish a novel humanized mouse model that can faithfully recapitulate HIV infection in...
- The National Institute of Mental Health (NIMH) awarded a $985,984 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. (HJF) to determine the interplay between mucosal-associated invariant T (MAIT) cells and the translocated microbiome in HIV-induced neuroinflammation. The key objectives are to longitudinally compare the relationships between the gut microbiome, MAIT cells in cerebrospinal...
- This $198,720 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855, the Allergy and Infectious Diseases Research program, will fund a 5-year study to investigate post-infectious dysautonomia in patients with Post-Acute Sequelae of COVID-19 (PASC) and Post-Treatment Lyme Disease (PTLD). The Johns Hopkins University will leverage its clinical resources to prospectively evaluate patients, conduct objective autonomic testing, analyze...
- This federal Project Grant award from the National Institutes of Health National Institute of Mental Health provides $6,499,884 to Yale University under the Mental Health Research Grants program (CFDA 93.242) to study the longitudinal nervous system consequences of SARS-CoV-2 in people with HIV-1 treated in early infection. The award will fund research from September 2022 to September 2025 to analyze pre- and post-COVID-19 data from a cohort of early antiretroviral therapy-treated people with...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,025,015 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Scintillon Institute in California. The grant, awarded on August 11, 2025, supports the development of a next-generation preclinical model of NeuroHIV that better recapitulates the neuro-immune-vascular system interactions in the context of antiretroviral therapy-mediated HIV suppression....
- The National Institutes of Health (NIH), through the Mental Health Research Grants program (CFDA 93.242) administered by the National Institute of Mental Health (NIMH), has awarded a $434,500 R21 grant to the University of California, San Diego (UCSD) to investigate the epigenetic mechanisms controlling HIV latency and neuropathogenesis in microglia. The project aims to use single-cell multi-omics approaches and state-of-the-art sequencing technologies to characterize the transcriptomic and...
- This Project Grant award from the National Institute on Drug Abuse (NIDA), part of the Department of Health and Human Services' Drug Use and Addiction Research Programs (CFDA 93.279), provides $147,486 to the Icahn School of Medicine at Mount Sinai to investigate the combined impact of HIV infection and nicotine use on neuroinflammation. The research aims to elucidate the role of the NLRP3 inflammasome in driving CNS inflammation, blood-brain barrier disruption, and viral reactivation in...
The U.S. National Institutes of Health (NIH) awarded a $789,126 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to the Icahn School of Medicine at Mount Sinai (ISMMS). The grant, titled "Complex Autonomic Neuropathic Dysfunction Leading to Gastrointestinal and Immune Effects in People with HIV (CANDLE)," will fund a longitudinal study of 125 people with HIV and 50 HIV-negative controls. The research will investigate how HIV-associated autonomic neuropathy affects gastrointestinal and immune function, including the impact of small intestinal bacterial overgrowth. The project will leverage gold standard autonomic function testing, continuous gut monitoring, and microbiome analysis to provide a multidimensional understanding of these complex effects. The award period runs from September 1, 2025 to June 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $789.1k | 8/22/25 |