This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $192,500.00 to the University of South Alabama for research focused on understanding the mechanisms of central nervous system invasion by the Lyme disease spirochete, Borrelia burgdorferi. The key objectives are to: 1) Determine the role of the blood-cerebrospinal fluid barrier as a site for B. burgdorferi and immune...
This federal Project Grant award for $1,663,244.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research to characterize innate immune signaling pathways in the tick Ixodes scapularis, which transmits Lyme and other emerging infectious diseases. The research aims to expand understanding of immune signaling in ticks, with the goal of identifying new interventions to...
This $382,500 five-year Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research supports research at Washington State University to study the functional and mechanistic aspects of the Lyme disease spirochete's genetic factors encoded on plasmid LP17. The key objectives are to: 1) Establish the importance of genes BBD21 and BBD22 for controlling the copy number of Borrelia burgdorferi plasmids and the...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $299,933 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to L2 Diagnostics LLC, a for-profit biomedical research company based in Woodbridge, Connecticut. The project aims to develop a novel therapeutic using a secretory leukocyte protease inhibitor (SLPI) to mitigate Lyme arthritis and post-treatment Lyme disease syndrome. The award period runs from July 8, 2024 to June 30, 2026....
The Virginia Commonwealth University was awarded a $746,009 Project Grant from the Department of Health and Human Services National Institutes of Health National Institute of Allergy and Infectious Diseases. The grant falls under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research examining the cyclic-di-GMP signaling pathway and its role in the enzootic cycle of Lyme disease from November 18, 2022 through October 31, 2027. Specifically, the grant will fund...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports a research project titled "Mechanistic Investigation of Neuropathological Interactions Between COVID-19 and Progression of Lewy Pathology and Dementia". The $506,052 award to Louisiana State University Health Sciences Center-Shreveport will fund a 1-year project...
This federal Project Grant award of $451,292.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to uncover neuronal mechanisms that orchestrate metabolic adaptations to bacterial infections, with a focus on delineating the role of the brain-liver axis in modulating metabolic responses. The research seeks to identify neurocircuits in the hypothalamus that monitor circulating lipoproteins and...
This $380,320 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to elucidate the dynamics of human CD8 T cell responses to SARS-CoV-2 and investigate how CD8 T cell homeostasis may be altered in Long COVID. The research aims to define the differentiation lineages of SARS-CoV-2-specific CD8 T cells, understand how epigenetic features influence their functional...
This $502,500 project grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award will fund research to elucidate the molecular mechanisms underlying ferrosome organelle biogenesis in the bacterium Clostridioides difficile, which is a leading cause of antibiotic-associated intestinal infections. The research aims to define how the ferrosome system enables C. difficile to adapt to iron...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $191,250 to Washington State University to conduct research on the mechanisms of antigenic variation in the Lyme disease spirochete, Borrelia burgdorferi. The research aims to determine the role of genetic factors, particularly guanine-rich DNA regions and a putative SpoVG binding site, in the expression and...
This Project Grant award, issued by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support a research project to investigate post-infectious dysautonomia. The $198,720 grant will fund a study led by a physician-scientist at Johns Hopkins University to identify distinct clinical subtypes of dysautonomia following COVID-19 and Lyme disease, examine the relationship between small-fiber neuropathy and disease severity, and discover novel autoantibodies targeting the sympathetic nervous system. The project aims to enhance the clinical research and biostatistical skills of the principal investigator while advancing scientific understanding of the mechanisms underlying post-infectious autonomic dysfunction, which can significantly impact recovery for patients with post-acute sequelae of COVID-19 and post-treatment Lyme disease.