This federal Project Grant award of $1,454,724 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to understand the mechanisms involved in HIV-1 latency in the central nervous system (CNS). The award aims to identify key factors, pathways, and regulators that determine the establishment, maintenance, and reactivation of latent HIV-1 virus in brain myeloid cell lineages, which are considered viral reservoirs in the...
This federal Project Grant award from the National Institutes of Health National Institute of Mental Health provides $6,499,884 to Yale University under the Mental Health Research Grants program (CFDA 93.242) to study the longitudinal nervous system consequences of SARS-CoV-2 in people with HIV-1 treated in early infection. The award will fund research from September 2022 to September 2025 to analyze pre- and post-COVID-19 data from a cohort of early antiretroviral therapy-treated people with...
The National Institutes of Health (NIH), through the Mental Health Research Grants program (CFDA 93.242) administered by the National Institute of Mental Health (NIMH), has awarded a $434,500 R21 grant to the University of California, San Diego (UCSD) to investigate the epigenetic mechanisms controlling HIV latency and neuropathogenesis in microglia. The project aims to use single-cell multi-omics approaches and state-of-the-art sequencing technologies to characterize the transcriptomic and...
This federal Project Grant award, funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), aims to evaluate social brain function in people living with HIV (PWH). The $733,355 award, effective March 1, 2025 through January 31, 2030, will utilize well-validated fMRI paradigms to examine neural circuits and performance related to two core social cognitive constructs: perceiving social cues (e.g., facial expressions, prosody) and...
This federal Project Grant award, totaling $745,822.00 and provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to investigate the role of the PERK kinase in HIV-induced neuroinflammation and neurocognitive impairment (NCI) in people with HIV (PWH). The University of Pennsylvania, as the primary grantee, will use biochemical, cellular, and pharmacologic approaches to assess PERK's potential as a predictive...
This $823,691 Project Grant award was provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) to investigate the role of immune checkpoints in the central nervous system (CNS) of people living with HIV (PLWH) and their association with HIV-associated neurocognitive disorder (HAND). The research aims to determine the profiles and biological functions of soluble immune checkpoints (sICPs) in the CNS of PLWH and a simian immunodeficiency...
This federal Project Grant award of $2,210,865, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), aims to identify unique neural and inflammatory mechanisms of depression in people living with HIV (PLWH). The University of California, Los Angeles (UCLA) will conduct a cross-sectional study to enroll PLWH who are depressed and non-depressed, as well as HIV-negative subjects who are depressed and non-depressed. The research...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $881,439 in funding to the University of North Carolina at Chapel Hill to conduct research on the evolution and latency of HIV in people infected with the subtype C virus. The key objectives of the project are to: determine the frequency of macrophage-tropic virus evolution in the central nervous system (CNS); identify which cell types in the CNS...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $678,674 to Rush University Medical Center to investigate the role of innate immunity in HIV-associated neurocognitive disorders (HAND) in the combination antiretroviral therapy (cART) era. The research aims to identify the molecular mechanisms triggering activation of intracellular innate immunity in microglia and characterize the cellular crosstalk...
This $103,948 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research on the impact of forced migration on HIV vulnerability and prevention among internally displaced adolescent girls and young women in Northern Mozambique. The project aims to (1) determine predictors of HIV vulnerability related to exposure to displacement-related stressors and mental health among this population, and (2) explore...
The National Institute of Mental Health (NIMH) awarded a $985,984 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. (HJF) to determine the interplay between mucosal-associated invariant T (MAIT) cells and the translocated microbiome in HIV-induced neuroinflammation.
The key objectives are to longitudinally compare the relationships between the gut microbiome, MAIT cells in cerebrospinal fluid, blood, gut, and brain during SHIV infection, post-antiretroviral therapy, and after analytical treatment interruption (Aim 1); and to determine the effects of the translocated microbiome on MAIT-neural cell interactions (Aim 2). This research will leverage previously collected biospecimens from a non-human primate study to comprehensively study MAIT cells across different compartments, with the goal of identifying MAIT cells as a potential key immune mediator of the gut-brain axis in people living with HIV. The award period runs from Sep 1, 2023 to Aug 31, 2025.
Additionally, Weill Medical College of Cornell University received a sub-award under this grant to support the research on determining the interplay of MAIT cells and the translocated microbiome in HIV-induced neuroinflammation.