This $818,886 Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) will support research at the University of California, San Diego (UCSD) to characterize the epigenetic regulation of the HIV provirus in brain myeloid cells from people with HIV (PWH). The key objectives are to: 1) Analyze the epigenetic characteristics of the HIV provirus in brain myeloid cells from 15 PWH, 2) Explore the mechanistic...
This $502,861 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research to investigate the role of the human protein PCIF1 in regulating interactions between the HIV virus and host cells. The key objectives are to: 1) Define the dynamics and mapping of human RNA methylome modifications induced by HIV infection and methamphetamine exposure; 2) Determine how HIV alters...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $1,668,032.00 to the University of Pittsburgh to conduct research into the mechanisms of HIV-1 latency in the central nervous system (CNS). The primary objectives are to identify key factors, pathways, and regulators that control the establishment, maintenance, and reactivation of latent HIV-1 reservoirs in CNS myeloid cell lineages,...
This Project Grant award of $881,439 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research to better understand the evolution and latency of T-tropic and M-tropic HIV in people infected with subtype C virus. The key objectives are to: Determine the frequency of macrophage-tropic virus evolution within the central nervous system (CNS), 2) Identify which cell types in the CNS are expressing virus, 3) Examine how...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $382,072 to George Washington University to conduct research on epigenetic mechanisms contributing to HIV-associated neurocognitive disorders (HAND). The primary objectives are to: 1) characterize the epigenetic modifications induced by HIV infection and HIV protein...
The National Institute of Mental Health (NIMH) awarded a $985,984 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. (HJF) to determine the interplay between mucosal-associated invariant T (MAIT) cells and the translocated microbiome in HIV-induced neuroinflammation. The key objectives are to longitudinally compare the relationships between the gut microbiome, MAIT cells in cerebrospinal...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $2,223,769 to the University of California, San Diego (UCSD) to investigate the intersection of HIV infection and opioid use on inflammation and neurotoxicity in the central nervous system. The 5-year study aims to analyze brain tissue samples from persons living with HIV and persons without HIV to determine the relationship between HIV activity,...
This federal Project Grant award for $745,822, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), is supporting research to investigate the role of the PERK enzyme in HIV-induced neuroinflammation and neurocognitive impairment. The project, led by the University of Pennsylvania, is employing biochemical, cellular, and pharmacological approaches to assess how PERK activity and signaling in different cell types (neurons,...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $211,950 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the University of California, Irvine to investigate the role of nucleic acid-containing immune complexes in driving immune activation and endothelial dysfunction in people living with HIV who are on antiretroviral therapy. The key research objectives are to: 1) Measure the inflammatory response to these nucleic acid-containing immune...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $2,210,865 to the University of California, Los Angeles (UCLA) to conduct research on identifying unique neural and inflammatory mechanisms of depression in people living with HIV (PLWH). The study will enroll 220 participants, including PLWH who are depressed, PLWH who are not depressed, and HIV-negative individuals who are depressed and not...