This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will provide $194,616 to The Johns Hopkins University to conduct research on the role of the G-protein coupled receptor GPR39 in kidney physiology. The research aims to uncover the mechanisms by which GPR39 activation influences water handling and reabsorption in the kidney, as well as the...
This $148,476 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate methods for long-term, kidney-specific depletion of resident macrophages as a potential therapeutic approach for autosomal dominant polycystic kidney disease (ADPKD). The research aims to map the kinetics and mechanism of kidney resident macrophage...
This federal Project Grant award, valued at $155,274.00 and provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA Program 93.847 "Diabetes, Digestive, and Kidney Diseases Extramural Research", aims to identify the neural and vascular mechanisms contributing to accelerated deterioration of kidney function in older adults with chronic kidney disease (CKD). The key objectives of this research project are to: 1) Determine if older CKD...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $531,999.00 in funding to The Washington University to investigate the role of alternative splicing in proximal tubule injury and diabetic kidney disease progression. The research aims to 1) define and validate the spectrum of alternative splicing in diabetic kidney disease and...
This federal Project Grant award for $689,095 was made by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to understand the ecological causes of gut microbiome dysbiosis in chronic kidney disease (CKD) and determine if these microbiome changes have a causative effect on CKD progression. Specifically, the research aims to investigate how...
This Project Grant award, with a total funding of $820,119, was granted by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The overarching goal of the research is to better understand the mechanisms that ensure podocyte homeostasis and the pathogenic mechanisms that promote podocyte foot process effacement, a hallmark of proteinuric glomerular diseases. The research seeks to...
This $391,250 federal Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award, with a project period from September 5, 2024 to August 31, 2026, will support research to investigate the critical role of extracellular vesicle (EV) fusion and delivery of adipose microRNAs into liver cells for metabolic signaling between these tissues....
This $603,632 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to define the role of the gene PLA2G12B in regulating the assembly, metabolism, and cardiovascular disease risk of triglyceride-rich lipoproteins. The research is being conducted by The Johns Hopkins University, a leading private research institution, and leverages novel...
This $199,999 Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports the development of innovative artificial intelligence (AI)-based methods to discover potent, orally available small-molecule heparanase inhibitors. Heparanase is an enzyme that plays a key role in the development of diabetic nephropathy, a complication of diabetes...
This $700,619 federal Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to study and control rhythmic nephron formation for kidney replacement tissues. The primary awardee, The Trustees of the University of Pennsylvania, aims to define the spatiotemporal coordination of cell-cell interactions that drive the rhythmic...