This $209,832 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) supports a 5-year research project titled "Deep Phenotyping of Autonomic Dysfunction in Chronic Kidney Disease" at New York University. The project aims to improve understanding of the role of the autonomic nervous system in the cardiovascular complications of chronic kidney disease, and to facilitate the career development of the principal investigator, Dr. Qandeel...
This federal Project Grant award of $671,986 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to strengthen the evidence-base for medication prescribing in older adults with chronic kidney disease (CKD). The primary objectives are to: 1) Evaluate the effectiveness of renoprotective therapies, such as angiotensin converting enzyme inhibitors (ACEIs) and sodium-glucose...
This $166,643 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports the development of robust phenotyping pipelines for early detection of collagen type IV-associated nephropathy (COL4A-AN) using electronic health records (EHR) data. The primary goal is to establish scalable phenotyping methods that leverage natural language processing (NLP) and...
This $142,902 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to uncover the mechanism by which the regulatory GTPase ARL13B drives polycystic kidney disease (PKD) pathogenesis. The research, led by Dr. Van Sciver at Emory University, will biochemically and genetically dissect ARL13B's interaction with three effector proteins - CDK1, ARL3,...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $154,381 to Dartmouth-Hitchcock Clinic to conduct a training and research program aimed at improving self-advocacy and outcomes for rural residents with chronic kidney disease (CKD). The key products and services to be delivered include: 1) Co-adapting an existing visit agenda-setting...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) will provide $596,345 to Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to investigate the molecular mechanisms underlying diabetic renal hypertrophy and its impact on acute kidney injury (AKI) susceptibility and severity in diabetes. The key objectives are to: (1) determine...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $358,062 to the University of Pittsburgh to conduct research on understanding kidney endothelial maturity and mesenchymal transition in vascularized human kidney organoids. The key objectives are to: 1) Determine if kidney organoid co-culture enables the induction of kidney-specific...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $168,886.00 to The University of Texas Southwestern Medical Center (UT Southwestern) to conduct research titled "Elucidating the Role of NAD+ and PARylation in Nephron Endowment." The award aims to study how maternal availability of nicotinamide adenine dinucleotide...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $114,180.00 to the Regents of the University of Minnesota to conduct research on renal afferent nerve circuitry and its influence on blood pressure regulation. The project aims to 1) elucidate the central terminations and regional specificity of renal afferents, and 2) identify...
This $820,119 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research focused on elucidating the mechanobiological functions of novel cytoskeletal structures in podocytes to reveal new therapeutic opportunities for kidney glomerular diseases. The primary research aims to better understand the mechanisms underlying podocyte homeostasis,...