The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $531,999 Project Grant under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research to The Washington University in St. Louis. This 4-year project aims to define and validate the spectrum of alternative splicing in diabetic kidney disease (DKD) models and test whether hypoxia drives proximal tubule alternative splicing via downregulation of the spliceosome regulator SRSF7. The research will also determine if alternative splicing regulation occurs in human DKD and if SRSF7 is required in the proximal tubule to promote a 'healthy' transcriptome. The findings could inform the development of future therapeutics targeting the renoprotective mechanisms of sodium-glucose cotransporter 2 inhibitors. As a prominent research institution, Washington University has extensive experience in federal biomedical research and development for agencies like the NIH.
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