Project Grant R01DK140070
Award Date
8/19/24
Completion Date
6/30/28
Dollars Obligated
$701K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Philadelphia, PA 19104, USA
Similar Awards
This federal Project Grant award of $421,067.00, awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), will fund research using kidney organoids to investigate the effects of in utero exposures, such as pregestational diabetes, on kidney development programs. The research aims to identify alterations to the normal differentiation of nephron progenitors and podocytes within the kidney...
The Department of Health and Human Services National Institutes of Health (NIH) awarded Duke University a $1,425,761 Project Grant under the Trans-NIH Research Support (CFDA 93.310) federal grant program. The purpose of this 3-year award is to harness stem cells and synthetic gene circuits to repair glomerular injury and address the significant burden of chronic kidney disease (CKD) and end-stage kidney disease (ESKD) in the U.S. and worldwide. The research will leverage Duke's expertise in...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $238,184 Project Grant (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to the University of Delaware to develop an easy-to-use 3D microphysiological system (MPS) that can spatially pattern the extracellular matrix, stromal cells, and soluble factors to recapitulate the developing nephron. The goal is to provide researchers without MPS expertise a tool to investigate the role and...
This $820,119 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research focused on elucidating the mechanobiological functions of novel cytoskeletal structures in podocytes to reveal new therapeutic opportunities for kidney glomerular diseases. The primary research aims to better understand the mechanisms underlying podocyte homeostasis,...
This $358,062 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to understand kidney endothelial maturity and mesenchymal transition in vascularized human kidney organoids. The research aims to: 1) Determine if kidney organoid co-culture enables engineered endothelial cells to undergo kidney-specific maturation, and 2)...
This $194,380.00 federal Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to understand the role of the protein LIM-nebulette in maintaining the structural integrity of podocytes - specialized cells within the kidney's filtration system. The research aims to examine how podocytes respond to mechanical stress, such as...
This Project Grant award in the amount of $168,886 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award will fund research at the University of Texas Southwestern Medical Center to elucidate the role of nicotinamide adenine dinucleotide (NAD+) and poly(ADP-ribose) polymerase 1 (PARP1) in fetal nephrogenesis and their potential to influence nephron...
This Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate gene regulatory networks related to hypoxia inducible factor-1A (HIF1A) in the kidney cortex and medulla. The $117,000 award will support the use of multiome data to validate transcription factor motifs and identify gene regulatory networks specific to the kidney...
This federal Project Grant award under the National Institute of Diabetes and Digestive and Kidney Diseases' (NIDDK) Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $464,940 to Seattle Children's Hospital, doing business as Seattle Children's Research Institute, to conduct research on the epigenetic regulation of kidney regeneration. The key products and services to be delivered under this 5-year award include: 1) defining proximal tubule cell states...
The federal Project Grant award R01DK141374, totaling $545,999.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to determine the mechanisms by which two key proteins, AXL and AIF-1, regulate the function of monocytes and macrophages in kidney transplant recipients. Specifically, the project will investigate how AXL influences early...