This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $603,632 to The Johns Hopkins University to define the role of the previously uncharacterized gene PLA2G12B in regulating the assembly, metabolism, and cardiovascular disease risk of triglyceride-rich apolipoprotein B-containing lipoproteins. The 5-year research project, running from March 2025 to December 2029, leverages novel in vivo reporter tools in zebrafish models to delineate how PLA2G12B interacts with other proteins involved in lipoprotein synthesis and trafficking. The findings aim to shed light on the poorly understood process of how triglycerides are incorporated into nascent lipoproteins, which can influence blood lipid levels and atherosclerosis risk.
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