Project Grant R01DE036327
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded Columbia University's Health Sciences Division a $655,455 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) effective September 11, 2025, with completion targeted for September 10, 2027. This R01 renewal award supports fundamental and translational research to identify temporomandibular joint (TMJ) cartilage progenitor cells and characterize their...
- The National Institute of Dental and Craniofacial Research awarded the University of Southern California $481,739 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop three-dimensional organoid models representing the stepwise neoplastic evolution of head and neck squamous cell carcinoma. The recipient institution will create organoids directly from normal human oral tissues, patient-derived leukoplakia samples, and head and neck squamous cell...
- The National Institute of Dental and Craniofacial Research awarded The Trustees of Columbia University in the City of New York $621,950 on August 6, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate mechanisms of scar-free ligament repair in zebrafish as a model for human musculoskeletal healing. The project dissects how zebrafish regulate extracellular matrix turnover during ligament injury to achieve regenerative healing without fibrosis, with the goal...
- The National Institute of Dental and Craniofacial Research, within the Department of Health and Human Services National Institutes of Health, awarded The Trustees of Columbia University in the City of New York $471,123 on August 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) for the AHEAD project (Adolescent Health and the Early-Life Dietary Exposome: Developing a Metabolomics-Based Index of Healthy Eating to Predict Children's Health Trajectories). The project...
- The National Institute of Dental and Craniofacial Research awarded The Trustees of Columbia University in the City of New York $329,000 on June 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to characterize the genetic and developmental mechanisms of mesencephalic trigeminal sensory cells in normal orofacial motor circuit maturation and in spinal muscular atrophy (SMA). The project investigates how sensory-motor circuits governing the transition from suckling to...
- The National Institute of Dental and Craniofacial Research awarded The Trustees of Columbia University in the City of New York $152,166 on September 4, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct research on blastema-driven craniofacial regeneration in zebrafish. The research investigates how multiple blastemas—regenerative cell clusters—coordinate to restore craniofacial joint tissues following injury. The project uses an adult zebrafish whole joint...
- The National Institute of Dental and Craniofacial Research, part of the Department of Health and Human Services National Institutes of Health, awarded the University of Illinois $249,000 on August 5, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop bone-like organoids that elucidate how immune responses influence craniofacial bone healing and regeneration. The recipient will establish bone-like organoids as predictive tools for craniofacial bone repair...
- The National Institute of Dental and Craniofacial Research awarded The Regents of the University of Colorado (University of Colorado-Denver) $552,009 on August 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop autologous organoid and humanized mouse models with thymic T cell education capacity for testing head and neck cancer immunotherapy. The award funds development of stem cell-derived thymic organoids (STOs) and isogenic multicellular models generated...
- The National Institute of Dental and Craniofacial Research awarded Icahn School of Medicine at Mount Sinai $150,590 on December 1, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to support research defining the role of tissue-resident macrophages (TRMs) during salivary gland morphogenesis. The research addresses salivary gland dysfunction caused by conditions such as Sjögren's syndrome and head and neck cancer irradiation, which lead to hyposalivation and...
- The National Institute of Dental and Craniofacial Research awarded New York University $656,068 on August 3, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to fund research into the neuronal mechanisms of lingual mechanosensation and nociception. The research investigates the molecular identities and functional roles of oral mechanosensory neurons and their contributions to oral health and pain disorders. The work focuses on tongue-innervating trigeminal neurons and...
The National Institute of Dental and Craniofacial Research awarded $597,769 to the Trustees of Columbia University in the City of New York on August 3, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121, a Project Grant). The award funds development of an engineered hydrogel-patient-derived organoid platform with tunable viscoelastic properties designed to model oral epithelial dysplasia and recapitulate the biomechanics of dysplasia and oral squamous cell carcinoma tissues. The research seeks to identify biomarkers and therapeutic strategies targeting the molecular mechanisms by which extracellular matrix viscoelasticity promotes dysplasia progression, with focus on CD44-dependent mechanotransduction pathways. The work includes three complementary aims: engineering the viscoelastic platform to define stiffness and viscosity thresholds regulating dysplasia phenotypes; elucidating how CD44 transduces mechanical cues into activation of tumor-promoting signaling; and validating therapeutically targeted mechanotransduction to suppress malignant transformation. Performance occurs in New York, NY with a period of performance through July 31, 2031. Columbia University's Health Sciences Division receives the award as the awardee.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $597.8k | 8/5/26 |