Project Grant R56DE029068
- This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is for the development and validation of a patient-specific TMJ-on-a-chip (TMJOC) model. The $738,929 award, granted on August 1, 2025, will be used to investigate multi-tissue crosstalk regulating temporomandibular joint (TMJ) disc injury and healing under inflammation and pathophysiological mechanical stimulation. The...
- This Project Grant award of $18,438.00, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research on cellular heterogeneity and niche regulation in temporomandibular joint (TMJ) osteoarthritis. The research aims to define unique cell subpopulations in the TMJ and examine how impaired organization of the fibrous superficial layers of the mandibular condyle alters TMJ progenitor cell...
- This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to identify the cellular origins of jaw joint cartilage regeneration in zebrafish. The award of $143,285.00 will allow the University of Southern California (USC) to optimize a transgenic model for ablating joint cartilage and investigate the sources of regenerating cartilage in this model. Specifically,...
- This Project Grant award of $419,379 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), is supporting research to investigate the molecular mechanisms by which Notch signaling regulates temporomandibular joint (TMJ) osteoarthritis. The goal is to develop new therapeutic approaches to prevent TMJ degeneration and facilitate regeneration. The award, with a performance period from August 2025...
- This federal Project Grant award of $589,135.00, awarded on August 22, 2025 by the National Institute of Dental and Craniofacial Research (NIDCR), supports the "Tissue-Immunoengineering of TMJ Neodisc Implants" research project at the University of California, Irvine. The goal of this project is to develop novel tissue engineering strategies, termed "tissue-immunoengineering", to create temporomandibular joint (TMJ) neodisc constructs that can effectively heal larger TMJ disc...
- This $507,006.00 Project Grant was awarded by the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), to The Children's Hospital of Philadelphia (CHOP). The grant supports research to investigate the role of hyaluronan, a key joint lubricant, in the maintenance and function of the temporomandibular joint (TMJ). Specifically, the project aims to study how hyaluronan regulates stem/chondroprogenitor...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $312,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the Regents of the University of Michigan Office of Research and Sponsored Projects to establish the Michigan Collaborative Hub for TMD Patient-Centric Research (MICH T PCR). The goal of the award is to transform the treatment of temporomandibular disorders (TMDs) through the translation of clinically-relevant innovations. The...
- This federal Project Grant award, valued at $294,000 and spanning September 2024 to September 2026, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant supports research to understand the mechanisms of craniofacial cartilage differentiation from human neural crest stem cells, with the goal of developing tissue engineering approaches to repair birth defects and injuries to the head and...
- The University of North Carolina at Chapel Hill received a $310,295 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant, awarded on September 11, 2025, with a completion date of September 10, 2027, supports research to identify subgroups of adolescents with chronic temporomandibular disorder (TMD) pain in order to guide personalized treatment approaches. The project aims to...
- This federal Project Grant award in the amount of $299,782.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The funding supports the development and validation of an MRI-compatible jaw metabolic stressor task to determine the jaw muscle metabolic stress and brain functional characteristics related to jaw pain perception during function. This research aims to create new models for studying...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $655,455 Project Grant to The Trustees of Columbia University in the City of New York under the Oral Diseases and Disorders Research (CFDA 93.121) program. The purpose of this 2-year award, effective from Sep 11, 2025 to Sep 10, 2027, is to investigate candidate temporomandibular joint (TMJ) cartilage progenitor cells and their regulatory niche critical for TMJ development, homeostasis, and regeneration. The research aims to establish the TMJ condyle as a model for studying cartilage progenitor cells and leverage these findings to design novel minimally invasive TMJ regenerative therapies. This foundational research is expected to advance fundamental knowledge about dental, oral, and craniofacial health and translate these findings into improved prevention, early detection, and treatment strategies for TMJ osteoarthritis.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $655.5k | 9/11/25 |