Project Grant R01DE036268
- The National Institute of Dental and Craniofacial Research awarded The Trustees of Columbia University in the City of New York $152,166 on September 4, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct research on blastema-driven craniofacial regeneration in zebrafish. The research investigates how multiple blastemas—regenerative cell clusters—coordinate to restore craniofacial joint tissues following injury. The project uses an adult zebrafish whole joint...
- The National Institute of Dental and Craniofacial Research awarded $597,769 to the Trustees of Columbia University in the City of New York on August 3, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121, a Project Grant). The award funds development of an engineered hydrogel-patient-derived organoid platform with tunable viscoelastic properties designed to model oral epithelial dysplasia and recapitulate the biomechanics of dysplasia and oral squamous cell carcinoma...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded Columbia University's Health Sciences Division a $655,455 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) effective September 11, 2025, with completion targeted for September 10, 2027. This R01 renewal award supports fundamental and translational research to identify temporomandibular joint (TMJ) cartilage progenitor cells and characterize their...
- The National Institute of Dental and Craniofacial Research, part of the Department of Health and Human Services National Institutes of Health, awarded the University of Illinois $249,000 on August 5, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop bone-like organoids that elucidate how immune responses influence craniofacial bone healing and regeneration. The recipient will establish bone-like organoids as predictive tools for craniofacial bone repair...
- The National Institute of Dental and Craniofacial Research awarded the University of Illinois $273,014 on March 1, 2030, under the Oral Diseases and Disorders Research program (CFDA 93.121) to support clinician-scientist training and research on NG2/CSPG4 signaling in mandibular endochondral fracture healing. The recipient will conduct laboratory experimentation and professional development to advance understanding of how mechanical loading-dependent NG2/CSPG4 signaling regulates the...
- The National Institute of Dental and Craniofacial Research awarded The Regents of the University of California, San Francisco $451,000 on August 6, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the mechanisms of intrafibrillar mineralization of collagen fibrils through the polymer-induced liquid precursor (PILP) pathway. The research examines how calcium and phosphate ions are captured and delivered to collagen mineralization sites, and explores the...
- The National Institute of Dental and Craniofacial Research, part of the Department of Health and Human Services National Institutes of Health, awarded $315,000 to the University of California, Los Angeles on July 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate bone morphogenetic protein (BMP)-dependent mechanisms underlying mandibular outgrowth and to resolve molecular pathways disrupted in micrognathia, a congenital anomaly affecting mandibular...
- The National Institute of Dental and Craniofacial Research awarded Oregon Health & Science University $900,000 on August 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the role of perivascular stromal cells in temporomandibular joint osteoarthritis progression. The research examines how perivascular stem and stromal cells within the temporomandibular joint synovium regulate joint homeostasis and contribute to osteoarthritis severity, with...
- The National Institute of Dental and Craniofacial Research awarded Old Dominion University Research Foundation $933,580 on June 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to support research on immunomodulatory therapeutic approaches to improve oral cavity wound healing. The project investigates FTY720, an active biolipid that targets the sphingosine pathway to attract proregenerative immune cells and improve healing of oronasal fistulae (ONF) while reducing...
- The National Institute of Dental and Craniofacial Research awarded the Stowers Institute For Medical Research $371,250 on March 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the pathogenesis, phenotypic variation, and prevention of craniofacial anomalies. The project examines how genetic and environmental factors interact to produce craniofacial birth defects—conditions such as cleft lip and palate, micrognathia, and craniosynostosis that account...
The National Institute of Dental and Craniofacial Research awarded The Trustees of Columbia University in the City of New York $621,950 on August 6, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate mechanisms of scar-free ligament repair in zebrafish as a model for human musculoskeletal healing. The project dissects how zebrafish regulate extracellular matrix turnover during ligament injury to achieve regenerative healing without fibrosis, with the goal of identifying molecular strategies applicable to human ligament and connective tissue repair. The research addresses fibrotic scar formation following ligament injuries, a major clinical problem currently limiting treatment outcomes. Work is performed in New York, New York. The period of performance runs through April 30, 2031. This is a project grant, a form of assistance funding supporting basic and translational research in dental, oral, and craniofacial health and disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $622.0k | 8/7/26 |