Project Grant R01DE032758
- The National Institute of Dental and Craniofacial Research awarded Trustees of Boston University $249,000 on May 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate neutrophil-sensory neuron interactions in dental pulp inflammation and pain. The research addresses pulpitis, an inflammatory disease of the dental pulp currently managed through invasive procedures such as root canal therapy and tooth extraction. The project examines how neutrophils drive...
- The National Institute of Dental and Craniofacial Research, an operating division of the Department of Health and Human Services National Institutes of Health, awarded Regents of the University of Michigan $600,214 on August 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to define the neuronal basis of odontogenic pain and identify targets for non-opioid analgesic development. The project, led by Dr. Joshua Emrick, investigates the cells, circuits, and behavioral...
- The National Institute of Dental and Craniofacial Research awarded the University of Southern California $481,739 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop three-dimensional organoid models representing the stepwise neoplastic evolution of head and neck squamous cell carcinoma. The recipient institution will create organoids directly from normal human oral tissues, patient-derived leukoplakia samples, and head and neck squamous cell...
- The National Institute of Dental and Craniofacial Research awarded The Trustees of The University of Pennsylvania $522,405 on May 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the role of taste receptor cells in periodontal homeostasis. The research focuses on how solitary chemosensory cells and macrophages in gingival tissue protect against periodontal disease through taste-like signaling pathways. The work addresses the mechanisms by which these...
- The National Institute of Dental and Craniofacial Research awarded the Regents of the University of Michigan $135,000 on August 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to support research dissecting the neural and molecular mechanisms of trigeminal low-temperature sensation. The funded research addresses orofacial neuropathic pain stemming from somatosensory nervous system dysregulation, including cold allodynia and cold hyperalgesia in conditions such as...
- The National Institute of Dental and Craniofacial Research awarded Duke University $444,125 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate central nervous system and autonomic correlates of temporomandibular disorder pain. The research characterizes how altered brainstem circuit activity and brain glymphatic flow relate to autonomic dysfunction in patients with chronic painful temporomandibular disorder (TMD). The project measures...
- The National Institute of Dental and Craniofacial Research awarded The Trustees of Columbia University in the City of New York $329,000 on June 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to characterize the genetic and developmental mechanisms of mesencephalic trigeminal sensory cells in normal orofacial motor circuit maturation and in spinal muscular atrophy (SMA). The project investigates how sensory-motor circuits governing the transition from suckling to...
- The National Institute of Dental and Craniofacial Research awarded the University of Rochester $415,813 on July 7, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop a modular microphysiologic system (MPS) for culturing three-dimensional innervated salivary gland tissue mimetics in array format. The funded research will create a platform capable of static and optional perfused culture of organoids and tissues arranged in arrays, addressing a gap in current...
- The National Institute of Dental and Craniofacial Research awarded the University of Rochester $111,828 on January 8, 2027, under the Oral Diseases and Disorders Research program (CFDA 93.121) to fund fellowship training in neural circuit research related to temporomandibular joint disorder. The project investigates central nervous system dysfunction underlying temporomandibular joint disorder pathophysiology, specifically testing the hypothesis that alterations in amygdala-brainstem circuitry...
- The National Institute of Dental and Craniofacial Research awarded the University of North Texas $142,235 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the relationship between tongue positioning and velopharyngeal insufficiency in individuals with velopharyngeal dysfunction secondary to cleft palate with or without cleft lip. The research addresses the persistent challenge that behavioral interventions to reduce hypernasality—a...
The National Institute of Dental and Craniofacial Research awarded New York University $656,068 on August 3, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to fund research into the neuronal mechanisms of lingual mechanosensation and nociception. The research investigates the molecular identities and functional roles of oral mechanosensory neurons and their contributions to oral health and pain disorders. The work focuses on tongue-innervating trigeminal neurons and their response to mechanical stimuli, including how oral pathologies such as tongue cancer, burning mouth syndrome, and ulcers affect mechanosensory function and trigger mechanical hypersensitivity and persistent pain that interferes with eating and speaking. The research examines whether mechanotransduction in these neurons operates independently of PIEZO2, the primary force transducer in the peripheral nervous system. Work is performed at New York University in New York, New York, with a period of performance from August 3, 2026, through July 31, 2031. The award is a Project Grant, which is the standard assistance type for individual investigator-initiated research supported by the National Institutes of Health.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $656.1k | 8/5/26 |