Project Grant R56DE034415
- This $515,926 Project Grant awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041) will fund research to develop an in vitro gingival (gum) tissue system to study the role of microbial communities on oral health and disease. The 5-year project, beginning June 1, 2024, will be conducted by the University of Massachusetts Lowell's Office of Research Administration-Lowell. The key objectives are: (1) developing and validating a microphysiological system to study oral...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $198,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Pennsylvania State University (Penn State) to conduct research on integrating population-wide oral microbiome data to better understand health differences in the United States. The project, which will run from July 1, 2025 to June 30, 2027, aims to disentangle how an individual's background and socioeconomic factors...
- This federal Project Grant award of $433,125.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to elucidate the role of sex hormones in influencing host-microbiome interactions in the human oral mucosa. The award will fund a 5-year project from August 1, 2025 to April 30, 2030, conducted by the University of Massachusetts Lowell. The research aims to develop a mechanistic...
- This $442,750 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will fund a research project titled "A Pathomimetic Gingiva-on-a-Chip for Assessing Microbiota-Directed Anti-Inflammatory Therapeutics" at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The project aims to identify metabolites that can selectively enhance beneficial oral...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $432,209 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to the University of California, Los Angeles (UCLA) for a 2-year period starting on August 1, 2023. The funding supports research to investigate the role of the CXCL10-CXCR3 axis in the compounding effects of diabetes mellitus on periodontitis. Specifically, the research aims to further elucidate the role of CXCL10 in the...
- This Project Grant award, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports a research project focused on investigating the biogenesis and localization of gingipains - critical virulence factors of the oral pathogen Porphyromonas gingivalis. The $358,823 grant, awarded to Loma Linda University, aims to expand the understanding of gingipains' hemagglutinating/adhesive properties and the...
- The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $273,009 Project Grant to Virginia Commonwealth University (VCU) to characterize a conserved streptococcal membrane protein affecting manganese utilization. The project aims to determine the crystal structure and functional role of this membrane protein, hypothesized to be an acyltransferase that incorporates polyunsaturated fatty acids...
- This federal Project Grant award for $331,999 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) aims to determine the causal relationship between poor oral health and heart disease. The primary awardee, Lehigh University, will construct polygenic scores using a GWAS-by-subtraction genomic structural equation model to identify genetic risk factors for poor oral health. They will then leverage this to...
- This federal Project Grant award of $163,411 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), supports research to characterize the nutritional niches and interactions between Streptococcus mutans, a primary driver of dental caries, and other commensal oral streptococci species. The research aims to understand how these microcolony biofilm structures form, the interactions between S....
- The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded a $511,706 Project Grant to the University of Florida for a 3-year study to determine whether frequent standardized oral care using human milk reduces oral/intestinal inflammation and microbial dysbiosis, leading to improved neonatal outcomes and reduced cost of care in preterm very low birth weight infants. The study aims to evaluate the effect of...
The University of Massachusetts Lowell (UML) received a $540,629 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The funding supports a 2-year research project to study host-pathogen interactions and modulation in an in vitro model of early oral dysbiosis. The project leverages UML's expertise in developing 3D oral tissue models that mimic the native gingival environment to investigate the interplay between the oral microbiome, host immune response, and development of oral inflammatory conditions like gingivitis. The research aims to advance fundamental understanding of the mechanisms driving oral disease progression, with the long-term goal of identifying predictive biomarkers and developing targeted intervention strategies to promote oral and overall health.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $540.6k | 8/15/25 |