Project Grant R01DE035109
- The National Institute of Dental and Craniofacial Research awarded Trustees of Boston University $249,000 on May 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate neutrophil-sensory neuron interactions in dental pulp inflammation and pain. The research addresses pulpitis, an inflammatory disease of the dental pulp currently managed through invasive procedures such as root canal therapy and tooth extraction. The project examines how neutrophils drive...
- The National Institute of Dental and Craniofacial Research awarded The Ohio State University $690,195 on March 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate neuroimmunological mechanisms regulating reparative dentinogenesis in response to deep tooth injuries and inflammation. The project examines how calcitonin gene-related peptide (CGRP) derived from sensory neurons regulates immune and mineralizing cell responses during tooth healing, specifically...
- The National Institute of Dental and Craniofacial Research awarded the Regents of the University of Michigan $135,000 on August 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to support research dissecting the neural and molecular mechanisms of trigeminal low-temperature sensation. The funded research addresses orofacial neuropathic pain stemming from somatosensory nervous system dysregulation, including cold allodynia and cold hyperalgesia in conditions such as...
- The National Institute of Dental and Craniofacial Research awarded $593,876 to the Regents of the University of Michigan on August 7, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the molecular mechanisms regulating peritubular dentin mineralization and develop bioengineered strategies for targeted dentin reconstruction. The research uses six mouse models with varied amounts of dentin sialoprotein (DSP), dentin phosphoprotein (DPP), and chondroitin...
- The National Institute of Dental and Craniofacial Research, part of the Department of Health and Human Services National Institutes of Health, awarded Michigan State University $298,613 on March 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate cellulose nanocrystals as a strategy for reducing moisture sensitivity in dental adhesives. The research will determine how cellulose nanocrystals distribute within self-etch adhesive formulations and whether...
- The National Institute of Dental and Craniofacial Research awarded Regents of the University of Michigan $312,000 on March 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate retinoic acid signaling in ameloblast differentiation during dental enamel formation. The research integrates single-cell RNA-sequencing data from 14 studies across mouse, rat, and human tooth development to determine ameloblast differentiation trajectories and elucidate the role...
- The National Institute of Dental and Craniofacial Research, part of the National Institutes of Health under the Department of Health and Human Services, awarded The University of Chicago $328,000 on August 5, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop and validate a microsimulation model of oral health lifetime outcomes and resource use in older adults. The project, titled "Development and Validation of the U.S. Oral Health Microsimulation...
- The National Institute of Dental and Craniofacial Research awarded New York University $656,068 on August 3, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to fund research into the neuronal mechanisms of lingual mechanosensation and nociception. The research investigates the molecular identities and functional roles of oral mechanosensory neurons and their contributions to oral health and pain disorders. The work focuses on tongue-innervating trigeminal neurons and...
- The National Institute of Dental and Craniofacial Research awarded the University of Pittsburgh $201,928 on December 19, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop a multimodal multi-electrode array for probing tooth root organoid maturation and sensory innervation. The research evaluates proper innervation of tooth root organoids derived from postnatal stem cells harvested during wisdom tooth extraction, investigating spatiotemporal dynamics of...
- The National Institute of Dental and Craniofacial Research awarded the Regents of the University of Michigan $583,620 on August 21, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to engineer transfer RNA-derived small RNAs (tsRNAs) as species-specific antimicrobial agents targeting oral pathobionts. The funded work develops chemically modified tsRNAs to suppress dental pathogens including Fusobacterium nucleatum, Porphyromonas gingivalis, and Treponema denticola while...
The National Institute of Dental and Craniofacial Research, an operating division of the Department of Health and Human Services National Institutes of Health, awarded Regents of the University of Michigan $600,214 on August 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to define the neuronal basis of odontogenic pain and identify targets for non-opioid analgesic development. The project, led by Dr. Joshua Emrick, investigates the cells, circuits, and behavioral phenotypes of toothache through three aims using mouse models and cutting-edge neuroscience approaches. Aim 1 will characterize peripheral mechanisms whereby intradental trigeminal sensory neurons are activated in pulpitis-induced pain. Aim 2 will define central mechanisms whereby intradental trigeminal sensory neuron inputs produce physiological responses. Aim 3 will establish novel preclinical phenotypes of odontogenic pain to provide objective measures for future analgesic evaluation. The work is performed at the University of Michigan in Ann Arbor, Michigan, with a period of performance from August 1, 2026, through May 31, 2031. This is a Project Grant, classified as assistance funding rather than a procurement contract.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $600.2k | 7/24/26 |