Project Grant R03DE034786
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research awarded the Regents of the University of Michigan a $135,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) for the period of August 1, 2025 through July 31, 2027. The grant supports research and development of bioinspired synthetic high-density lipoprotein (SHDL) nanotherapeutics designed to treat apical periodontitis (AP) and promote dental pulp and dentin regeneration....
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $476,287 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the Regents of the University of Michigan on April 9, 2025. The grant supports research to investigate the role of the MERTK receptor tyrosine kinase in alveolar bone regeneration following tooth extraction. The research aims to determine the effects of MERTK signaling on alveolar bone stem cells and the recruitment and...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research awarded The Research Foundation for the State University of New York a Project Grant of $320,200 (awarded July 15, 2025, with completion anticipated July 14, 2027) under the Oral Diseases and Disorders Research program (CFDA 93.121). This award funds research to define the gene regulatory mechanisms of MLL4 (KMT2D), an epigenetic coactivator, in tooth enamel development and amelogenesis. The research...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded The Research Foundation for the State University of New York $870,334 under the Oral Diseases and Disorders Research program (CFDA 93.121) for a two-year project grant running from August 1, 2025, through July 31, 2027. The project focuses on developing an early tooth organoid using human induced pluripotent stem cells (iPSCs) to address gaps in understanding tooth development and disease...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $421,800 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to Midwestern University. The purpose of this 3-year grant, with a start date of September 7, 2023, is to develop hybrid hydrogel-based dental adhesives that are less vulnerable to hydrolytic degradation compared to current methacrylate-based alternatives. The goal is to create a truly biomimetic dental adhesive that can not only...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the University of Southern California $1,300,530 under the Oral Diseases and Disorders Research program (CFDA 93.121) on April 10, 2025, with a completion date of January 31, 2030. This Project Grant supports fundamental research investigating phosphate (inorganic phosphate) cellular transport mechanisms and their critical role in dental enamel mineralization. The research addresses a...
- This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $429,000.00 to the Regents of the University of Michigan to conduct research on the unique characteristics of jawbone biology. The research aims to gain a molecular-level understanding of how osteoblasts in the jawbone respond differently to bone morphogenetic protein (BMP) signaling and mechanical loading...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the Regents of the University of Michigan a Project Grant of $527,732 under the Oral Diseases and Disorders Research program (CFDA 93.121) effective February 15, 2026, with completion targeted for January 31, 2031. The grant supports research investigating the role of tissue homeostasis in Sjögren's Disease (SJD), a chronic autoimmune condition characterized by immune cell infiltration of...
- Federal Grant Award Summary The University of Alabama at Birmingham received a $594,000 Project Grant from the National Institute of Dental and Craniofacial Research under the Oral Diseases and Disorders Research program (CFDA 93.121) awarded August 1, 2025, with completion targeted for July 31, 2027. The award funds research investigating new molecules involved in tooth and root developmental anomalies, specifically Short Root Anomaly (SRA), a dental developmental disorder characterized by...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the University of Maryland, Baltimore a Project Grant of $427,625 under the Oral Diseases and Disorders Research program (CFDA 93.121) for the period of July 1, 2025 through June 30, 2027. This award supports a two-year research initiative investigating the association between denosumab (DMAB) therapy and multiple external cervical root resorption (MECRR), a pathological dental condition...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $312,000 Project Grant to the Regents of the University of Michigan, effective March 1, 2026 through February 28, 2028, under the Oral Diseases and Disorders Research program (CFDA 93.121). The research project aims to elucidate the role of retinoic acid (RA) signaling in ameloblast differentiation and dental enamel formation. The primary deliverables include comprehensive single-cell and spatial transcriptomic analyses of developing teeth, integration of scRNA-seq data from 14 studies across multiple tooth types in mice, rats, and humans, and biological validations to determine the ameloblast differentiation trajectory. The research will identify critical genes and retinoic acid response elements that specify sequential ameloblast differentiation stages, particularly examining how RA signaling transitions from inhibition in pre-secretory ameloblasts to activation in secretory-stage ameloblasts. The grant supports fundamental research designed to advance understanding of dental stem cell commitment and ameloblast lineage development, with findings intended to inform prevention and treatment strategies for dental health conditions. Deliverables include detailed characterization of dental epithelial stem cell (DESC) diversification patterns, identification of novel ameloblast differentiation clusters, and validation of the RA signaling pathway's role in enamel formation through molecular analyses conducted at the University of Michigan's Ann Arbor campus.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $312.0k | 2/18/26 |