Project Grant R01DE035828
Award Date 8/7/26
Completion Date 5/30/31
Dollars Obligated $594K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Ann Arbor, MI 48109, USA
Similar Awards
- The National Institute of Dental and Craniofacial Research awarded The Regents of the University of California, San Francisco $451,000 on August 6, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the mechanisms of intrafibrillar mineralization of collagen fibrils through the polymer-induced liquid precursor (PILP) pathway. The research examines how calcium and phosphate ions are captured and delivered to collagen mineralization sites, and explores the...
- The National Institute of Dental and Craniofacial Research awarded Texas A&M University System Health Science Center $346,500 on April 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the molecular pathogenesis of dentinogenesis imperfecta caused by mutations affecting dentin sialophosphoprotein preprotein signal peptide removal. The research focuses on non-syndromic dentinogenesis imperfecta, the most common inherited dentin disorder, which...
- The National Institute of Dental and Craniofacial Research awarded Regents of the University of Michigan $312,000 on March 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate retinoic acid signaling in ameloblast differentiation during dental enamel formation. The research integrates single-cell RNA-sequencing data from 14 studies across mouse, rat, and human tooth development to determine ameloblast differentiation trajectories and elucidate the role...
- The National Institute of Dental and Craniofacial Research, part of the Department of Health and Human Services National Institutes of Health, awarded Michigan State University $298,613 on March 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate cellulose nanocrystals as a strategy for reducing moisture sensitivity in dental adhesives. The research will determine how cellulose nanocrystals distribute within self-etch adhesive formulations and whether...
- The National Institute of Dental and Craniofacial Research, an operating division of the Department of Health and Human Services National Institutes of Health, awarded Regents of the University of Michigan $600,214 on August 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to define the neuronal basis of odontogenic pain and identify targets for non-opioid analgesic development. The project, led by Dr. Joshua Emrick, investigates the cells, circuits, and behavioral...
- The National Institute of Dental and Craniofacial Research awarded The Children's Hospital Corporation, doing business as Boston Children's Hospital, $539,217 on September 3, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the microbiology of dentin invasion in dental caries. The project addresses how cariogenic microbes invade dentin—the tooth structure beneath enamel—and reach the pulp, causing toothaches, periapical inflammation, abscess, and systemic...
- The National Institute of Dental and Craniofacial Research awarded The Ohio State University $690,195 on March 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate neuroimmunological mechanisms regulating reparative dentinogenesis in response to deep tooth injuries and inflammation. The project examines how calcitonin gene-related peptide (CGRP) derived from sensory neurons regulates immune and mineralizing cell responses during tooth healing, specifically...
- The National Institute of Dental and Craniofacial Research awarded The Ohio State University $469,207 on February 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct pharmacological inhibition of ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) to promote cementum regeneration and restore periodontal attachment and function. The research addresses periodontal disease and cementum defects, particularly in hypophosphatasia (HPP), a mineralization...
- The National Institute of Dental and Craniofacial Research awarded the Regents of the University of Michigan $429,000 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the role of autophagy in enamel development and amelogenesis imperfecta. The research addresses amelogenesis imperfecta, a congenital tooth enamel defect characterized by abnormally thin, soft, fragile, and discolored enamel that causes social embarrassment, dental pain,...
- The National Institute of Dental and Craniofacial Research awarded Regents of the University of Michigan $442,870 on August 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct genetic research on hereditary enamel defects. The project, titled "Discovery, Validation, and Mitigation of Genetic Mutations Underlying Hereditary Enamel Defects," integrates developmental and intervention genetics to advance knowledge and identify therapeutic premises for...