Project Grant R01DE035477
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded The Ohio State University a Project Grant of $469,207 under the Oral Diseases and Disorders Research program (CFDA 93.121) for the period February 1, 2026, through January 31, 2028. The grant supports research investigating pharmacological inhibition of ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) as a therapeutic approach to promote cementum regeneration and periodontal tissue...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $310,615 project grant to The Ohio State University, effective March 10, 2025, through February 28, 2027, under the Oral Diseases and Disorders Research program (CFDA 93.121). This research initiative, titled "Nutritional Niches Within Supragingival Biofilms," focuses on fundamental investigations into the microbial interactions and nutritional partitioning that occur within...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded The Ohio State University a Project Grant of $693,179 under the Oral Diseases and Disorders Research program (CFDA 93.121) on August 11, 2025, with a completion date of May 31, 2030. This research initiative examines the relationship between Medicaid reimbursement policies for Silver Diamine Fluoride (SDF) treatment and pediatric oral health outcomes across states. The project employs a...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded The Research Foundation for the State University of New York $870,334 under the Oral Diseases and Disorders Research program (CFDA 93.121) for a two-year project grant running from August 1, 2025, through July 31, 2027. The project focuses on developing an early tooth organoid using human induced pluripotent stem cells (iPSCs) to address gaps in understanding tooth development and disease...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research awarded Cleveland Clinic Lerner College of Medicine of Case Western Reserve University $442,750 under the Oral Diseases and Disorders Research program (CFDA 93.121) on August 14, 2025, with completion targeted for August 13, 2027. This project grant supports the development of a pathomimetic gingiva-on-a-chip model designed to evaluate microbiota-directed anti-inflammatory therapeutics for...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded The Ohio State University a $645,988 Project Grant effective August 13, 2025, through August 12, 2027, under the Oral Diseases and Disorders Research program (CFDA 93.121). This research initiative investigates the role of bacteriophages—viruses that infect bacteria—in the development of early childhood caries (ECC) and explores their potential therapeutic applications. The multi-investigator...
- Federal Grant Award Summary The University of Pittsburgh received a $100,676 Project Grant from the National Institute of Dental and Craniofacial Research under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded December 19, 2025, with completion targeted for August 31, 2027. This research initiative develops advanced multimodal microelectrode array (MEA) technology to investigate tooth root organoid maturation and sensory nerve innervation. The project addresses a...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research awarded a $521,362 Project Grant to The Johns Hopkins University beginning August 12, 2025, and concluding August 11, 2027, under the Oral Diseases and Disorders Research program (CFDA 93.121). The award supports fundamental research aimed at decoding neuroimmune interactions to enhance craniofacial bone healing. The research will employ quantitative light-sheet microscopy (QLSM) and single-cell RNA sequencing...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded Oregon State University a $422,665 Project Grant on June 17, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop an integrated dental plaque bioanalytical platform for point-of-care diagnostics of oral diseases. The research addresses the significant financial burden of dental caries by creating a quantitative electrochemical biosensing platform capable...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research awarded the Regents of the University of Michigan a $135,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) for the period of August 1, 2025 through July 31, 2027. The grant supports research and development of bioinspired synthetic high-density lipoprotein (SHDL) nanotherapeutics designed to treat apical periodontitis (AP) and promote dental pulp and dentin regeneration....
The National Institute of Dental and Craniofacial Research awarded The Ohio State University $690,195 under the Oral Diseases and Disorders Research program (CFDA 93.121) on March 1, 2026, for a five-year project grant extending through February 28, 2031. This project grant supports research investigating the neuroimmunological mechanisms regulating reparative dentinogenesis—the biological process of dentin repair following deep tooth injury and inflammation. The research aims to understand how calcitonin gene-related peptide (CGRP), a neuronal-derived signaling molecule, activates immune cells (neutrophils and monocytes) and mineralizing cells (odontoblasts and their progenitors) to promote pulp healing and tissue repair rather than tooth extraction and replacement with artificial materials. The project deliverables focus on advancing vital pulp therapies (VPTs) through basic and translational research that elucidates cellular crosstalk mechanisms during tooth healing. The research will generate scientific knowledge regarding cell-specific effects of CGRP signaling in the context of deep dentin trauma, with findings intended to identify therapeutic strategies that harness the neuron-immune-stem cell axis to preserve tooth vitality. This research addresses a significant public health need, as deep tooth injuries and pulpal inflammation affect millions of Americans and currently result in pulp devitalization and replacement with non-biological materials when conventional therapies prove ineffective.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $690.2k | 2/19/26 |