This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), totaling $557,606.00, supports research aimed at advancing the understanding of periodontal stem cells and their regulation for more predictable and efficient periodontal tissue regeneration. The key research objectives are to: 1) characterize the properties of periodontal crestal stem cells (PCSCs) and their activation by injury; 2) determine the signaling pathways regulating PCSC activation and lineage-specific differentiation during periodontal tissue repair; and 3) evaluate the roles of CXCL12 and SHH in periodontal tissue regeneration in a periodontitis mouse model. The award will be used to conduct comprehensive scientific investigations, including molecular and cellular studies, tissue engineering research, and in vivo experiments, with the goal of developing new insights into periodontal stem cell biology and advancing treatment approaches for periodontal diseases. The award period runs from April 16, 2025 to March 31, 2030.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $557.6k | 4/16/25 |