Project Grant R01DA064646
- The University of Kentucky Research Foundation received a $1.85 million Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded July 1, 2025, with completion targeted for February 29, 2028. This human laboratory study investigates the use of pentoxifylline, an FDA-approved phosphodiesterase inhibitor currently used to treat peripheral artery disease, as a potential therapeutic intervention for cocaine use...
- Federal Project Grant Award Summary Wake Forest University Health Sciences received a $758,218 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) effective September 1, 2025, through May 31, 2030. This award supports translational research investigating nociceptin/orphanin FQ peptide (NOP) receptor agonists as potential pharmacotherapies for cocaine use disorder (CUD), addressing a critical public health gap given...
- Wake Forest University Health Sciences received a $952,155 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) awarded August 15, 2025, with an ultimate completion date of April 30, 2030. The grant supports research investigating the impact of nicotine and alcohol co-use on the abuse potential of cocaine using cynomolgus monkey models. This work addresses the critical public health challenge of cocaine use disorder...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded $880,000 in project grant funding to the University of Texas Medical Branch at Galveston on July 15, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to support research addressing cocaine use disorder (CUD). The award funds a two-year research initiative (completion date: June 30, 2027) investigating GPR6 (G protein-coupled receptor 6) as a potential therapeutic target for CUD...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the University of Texas Health Science Center at Houston a $2.09 million Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) for a pilot mechanistic study investigating semaglutide as a treatment for cocaine use disorder (CUD). Effective June 15, 2025, through February 28, 2029, this R01 Stage IIA study addresses a critical public health need, as approximately 1.4 million Americans met...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The University of Kentucky Research Foundation a Project Grant of $1,463,994 under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct clinical research on non-abstinence treatment outcomes for methamphetamine use disorder (MUD). The award, obligated on September 30, 2025, with completion anticipated by May 31, 2030, funds a randomized controlled trial examining how reduced methamphetamine...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded $647,142 to The University of Kentucky Research Foundation under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct controlled research examining the impact of cannabis on opioid self-administration in individuals with opioid use disorder (OUD). The project, initiated February 15, 2026 and concluding November 30, 2030, addresses a critical public health gap by providing the first controlled data on...
- This $2.275 million Project Grant awarded by the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279) supports a research initiative at Vanderbilt University beginning July 1, 2025, and extending through March 31, 2030. The project, titled "Molecular Determinants of Ensemble Recruitment by Drugs of Abuse," investigates how cocaine-activated neuronal ensembles are recruited and maintained within the nucleus accumbens—a key reward-related...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the University of Texas Medical Branch at Galveston a $795,090 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) effective September 1, 2025, with a completion date of May 31, 2030. This award supports discovery and development of small molecule ligand probes targeting GPR52 (G protein-coupled receptor 52) as a novel therapeutic approach for cocaine use disorder (CUD). The research...
- Summary of Federal Cooperative Agreement Award Virginia Commonwealth University received a $643,019 Cooperative Agreement award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct a proof-of-concept randomized controlled trial evaluating psilocybin-assisted treatment for cocaine use disorder (CocUD). The award, effective July 15, 2025, through June 30, 2027, supports research combining psilocybin with psychedelic...
The National Institute on Drug Abuse (NIDA) awarded The University of Kentucky Research Foundation a $663,978 Project Grant on May 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct translational research evaluating Cobenfy as a potential treatment for cocaine use disorder (CUD). The project will deliver clinical and preclinical research services through May 28, 2031, involving human laboratory studies with individuals meeting CUD criteria who will be maintained on Cobenfy or placebo and participate in money-versus-intravenous cocaine choice sessions to assess the drug's efficacy in reducing cocaine self-administration. The award supports a cross-species translational research approach examining the dose-dependence and time course of Cobenfy's effects on cocaine choice in both human subjects and rat models using established choice procedures designed to predict clinical efficacy. This research addresses a significant public health need by investigating whether Cobenfy, a newly FDA-approved schizophrenia medication containing the M1/M4-preferring agonist xanomeline combined with the peripheral muscarinic antagonist trospium, can effectively reduce cocaine use. The project leverages prior preclinical findings demonstrating xanomeline's promise in attenuating cocaine effects and extends this translational work into human laboratory settings to advance understanding of muscarinic receptor modulation as a treatment strategy for substance use disorders.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $664.0k | 5/1/26 |