Project Grant R01DA062224
- This federal Project Grant award of $795,090 from the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to support research on the discovery of GPR52 ligand probes for the treatment of cocaine use disorder. The key products and services to be delivered under this award include: Establishing and validating GPR52-based cellular assays to identify small molecule GPR52 agonists Designing a...
- This Project Grant award of $405,230 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to advance NR4A1 as a novel target for treating cocaine use disorder. The key objectives are to: 1) Synthesize and screen derivatives of the NR4A1 agonist Cytosporone B to identify lead compounds, and 2) Establish milestones towards filing a commercially-viable Investigational New Drug (IND) application for an NR4A1-targeted...
- This $436,050 federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to investigate cell type and circuit-specific epigenetic mechanisms underlying cocaine addiction. The research will utilize a mouse model of repeated cocaine exposure to study how cocaine-induced molecular changes in specific brain regions and neuronal circuits lead to the development of addictive behaviors. The goal is to...
- This Project Grant award from the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, under the Drug Use and Addiction Research Programs (CFDA 93.279), will provide $474,347 to Wake Forest University Health Sciences (WFUHS) to investigate the impact of nicotine and alcohol co-use on the abuse potential of cocaine in monkey models. The goal is to extend the study of cocaine misuse to include the co-use of nicotine and/or alcohol, examining behavioral and...
- This Project Grant award for $440,000, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to investigate the therapeutic potential of the G protein-coupled receptor GPR6 as a novel target for treating cocaine use disorder. The key objectives include: 1) examining GPR6 expression in specific neuron subpopulations involved in cocaine reward processing, 2) evaluating GPR6 status following intravenous self-administration...
- This federal Project Grant award of $121,323.00 was provided by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant will support research by the University of North Carolina at Chapel Hill to investigate the structural and functional responses of nucleus accumbens microglia following long-access cocaine self-administration. The research aims to elucidate the role of microglia and...
- The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), awarded a $1,240,766 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The University of Kentucky Research Foundation. The grant, titled "Targeting Immune Inflammation in Cocaine Use Disorder: A Human Laboratory Study with Pentoxifylline," aims to investigate whether targeting neuroimmune signaling can affect the response to cocaine use and serve as a...
- This federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) totaling $1,447,919.00 supports research on the "Cocaine Addition and the Need-State Hypothesis." The research project aims to test the hypothesis that addiction involves the hijacking of physiological need substrates, in addition to reward substrates. Specifically, the project will evaluate whether treatment with a Glucagon-Like Peptide-1...
- This $149,284 Project Grant award from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) to Vanderbilt University will fund research to understand how chronic cocaine use disrupts the neural processing of aversive, non-drug stimuli in the brain. The study aims to define the precise temporal parameters under which dopamine release modulates the activity of genetically-defined neuron populations in the nucleus accumbens, both at baseline and in...
- This Project Grant award from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) provides $702,965 to the University of Texas Health Science Center at Houston to conduct a pilot mechanistic study on repurposing the drug semaglutide for the treatment of cocaine use disorder. The study aims to provide proof-of-concept evidence that semaglutide, a glucagon-like peptide receptor agonist, can modulate key reward-related mechanisms underlying cocaine use,...
This federal Project Grant award of $758,218 from the National Institute on Drug Abuse (NIDA), part of the Drug Use and Addiction Research Programs (CFDA 93.279), supports research on the potential of nociceptin/orphanin FQ peptide (NOP) receptors as targets for novel pharmacotherapies to treat cocaine use disorder (CUD) in non-human primate models. The key products and services to be delivered under this award include: Examining how NOP receptors influence vulnerability to developing CUD using PET imaging to determine the relationship between drug-naive monkeys' NOP receptor binding and sensitivity to cocaine during initial cocaine self-administration. Identifying changes in brain NOP receptors through repeated PET scans during long-term cocaine self-administration in non-human primates. Assessing the ability of NOP-acting drugs, including buprenorphine analogs, to decrease cocaine self-administration in a highly relevant non-human primate model of CUD and treatment evaluation. The award period runs from September 1, 2025 to May 31, 2030 and is being conducted by the lead grantee, Wake Forest University Health Sciences.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $758.2k | 8/22/25 |