This federal Project Grant award of $180,606.00 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) is funding research to investigate cocaine-induced proteomic adaptations in the nucleus accumbens region of the brain. The principal investigator will use a combination of behavioral, cellular/molecular, and bioinformatic approaches to characterize the cell-type and circuit-specific synaptic proteome changes in response to cocaine...
This Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to determine the mechanisms by which cocaine affects striatal circuit activity and facilitates cocaine seeking and taking behaviors. The $226,295 award, with a performance period from August 15, 2024 to May 31, 2027, will enable the University of Texas at Austin to: 1) investigate the role of striatal enkephalin in cocaine-induced...
This Project Grant award of $702,965 was provided by the National Institute on Drug Abuse (NIDA) under the federal Drug Use and Addiction Research Programs (CFDA 93.279). The purpose of the award is to conduct a pilot mechanistic study to evaluate the potential of the drug semaglutide, a glucagon-like peptide receptor agonist (GLP-1RA), as a treatment for cocaine use disorder (CUD). The 4-year study, which will run from June 2025 to February 2029, will assess semaglutide's impact on key...
The National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded a $400,000 Project Grant to Iontx Inc., a woman-owned small business located in Friendswood, Texas. The goal of this 12-month grant, which runs from May 15, 2025 to April 30, 2026, is to conduct structure-activity relationship (SAR) analysis and optimization of a novel small-molecule compound, 5788, that enhances the FGF13/NAV1.6 complex. This compound has shown potential to...
The National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), awarded a $118,656 Project Grant to the Ponce Medical School Foundation Inc. (doing business as Ponce School of Medicine) in Puerto Rico. The grant, awarded on November 29, 2024, supports research to investigate the influence of fear conditioning and cocaine exposure on cocaine-seeking behavior in male and female rats. The project aims to analyze the synaptic changes in the...
This $234,000 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research at Oregon Health & Science University (OHSU) to investigate rapid protein translation in nucleus accumbens neurons in response to a cocaine-associated cue. The goal is to use translating ribosome affinity purification and RNA sequencing (TRAP-seq) to identify mRNAs that are actively translating during re-exposure to cocaine...
This $149,284 Project Grant award from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) to Vanderbilt University will fund research to understand how chronic cocaine use disrupts the neural processing of aversive, non-drug stimuli in the brain. The study aims to define the precise temporal parameters under which dopamine release modulates the activity of genetically-defined neuron populations in the nucleus accumbens, both at baseline and in...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), is providing $174,029.99 to the University of California, Irvine to investigate the role of the GILZ gene in regulating cocaine-induced cellular activity and cocaine-associated memory formation. The research aims to elucidate how the GILZ gene, which is located on the X chromosome, may contribute to sex-dependent differences in responses to...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $291,848 to The Medical College of Wisconsin, Inc. to conduct research on the involvement of GQ signaling in the mobilization of 2-arachidonoylglycerol by corticosterone in the prefrontal cortex. The goal is to examine the hypothesis that GQ-coupled GPCR signaling is required for the rapid corticosterone mobilization of 2-AG in the...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,996,709.00 to the Trustees of Indiana University, doing business as Indiana University Indianapolis, for a project titled "Involvement of Cortical Excitatory Projections in Cocaine Addiction." The project aims to investigate the role of cortical pyramidal neurons in the supplementary motor cortex and their impact on glutamate...