This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), will support a $346,911 cross-species research study to identify early life environmental and genetic risk factors for substance use disorders (SUDs). The key objectives are to: 1) determine how early life environment influences neurocognitive development and its relationship to adult impulsivity behaviors; 2) identify genomic networks associated...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,373,618.00 to conduct a mechanistic investigation to further validate a human sign-/goal-tracking paradigm and identify neurobehavioral signatures of sign- and goal-tracking. The research aims to characterize the neurobehavioral differences between sign-tracking (associated with bottom-up processing and heightened reward responsivity)...
The National Institute on Drug Abuse (NIDA) awarded a $1,039,420 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The Medical University of South Carolina (MUSC). The grant, effective June 1, 2025 through February 28, 2030, will support research to characterize the transcriptomic profile and function of single neurons and unique neuronal ensembles in brain circuits that govern the facilitation and disinhibition of alcohol and opioid seeking behaviors. The project...
The University of Washington was awarded a $149,284 Project Grant by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the role of specific subpopulations of prefrontal cortex pyramidal neurons in regulating drug-seeking behavior. The research aims to elucidate the factors that predispose individuals to addiction and confer vulnerability to relapse, with the goal of advancing understanding of the functional roles of...
This $265,302 Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to investigate the neural mechanisms underlying opioid use disorder (OUD) and relapse risk during abstinence. The funded project will map the functional and anatomical pathways between the anterior and posterior paraventricular nucleus of the thalamus (PVT) and the nucleus accumbens (NAc), which have been implicated in the...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $629,844 to Duke University to conduct research on the role of the ventral tegmental area (VTA) in motivated behavior. The key research objectives are to: Elucidate the function of VTA circuits using a multi-level approach combining optogenetics, in vivo electrophysiology, photometry, and quantitative behavioral measures to understand the...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,080,885 to the University of Southern California (USC) from September 2024 to September 2027. The funding supports the development of novel neural network models that can capture the nonlinear dynamics of large-scale brain networks and their relationship to behavior. The models will have flexible inference capabilities, enabling real-time,...
This $2,838,472 Project Grant award from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) supports a 5-year research project at Brown University to investigate cannabis use trajectories among young adults. The key objectives are to: Characterize the micro-transitions (frequent, smaller-scale changes) in cannabis use during young adulthood (ages 18-25) and the associated factors, such as access to alternative reinforcers, delay discounting, and...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to optimize an online behavioral intervention to prevent and reduce substance use among high school seniors, a critical transition period. The $1,702,558 award will fund the development and evaluation of an innovative, technology-driven intervention targeting social influences linked to substance use. The project will employ human-centered...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $417,861.00 to investigate the neural mechanisms underlying individual differences in reward-based learning strategies and their relationship to addiction-like behaviors. The 5-year research project, conducted by the Regents of the University of Minnesota, will focus on the role of dopamine signaling in the basolateral amygdala in mediating the...