The National Institute on Drug Abuse (NIDA) awarded a $818,513 Project Grant (CFDA 93.279 - Drug Use and Addiction Research Programs) to the Regents of the University of Minnesota to investigate the role of dopamine signaling in the basolateral amygdala in regulating individual differences in reward-based learning strategies and addiction-like behaviors. The 5-year grant, which commenced on Sep 15, 2024, will focus on examining how individual differences in Pavlovian reward learning approaches...
This $2,419,326 Project Grant awarded by the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports a longitudinal study to investigate neurobehavioral and psychosocial predictors of health risk behaviors (HRBs) in adolescence and young adulthood. The primary awardee, Virginia Polytechnic Institute & State University, will conduct assessments over 15 years to understand brain development and its impact on substance use and...
This Project Grant award of $250,568.00 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will fund a 3-year research project to investigate the neurobiological mechanisms underlying individual and sex differences in emotional cue processing related to addiction and post-traumatic stress disorder. The award recipient, the Regents of the University of Michigan, will use chemogenetic and fiber photometry techniques to gain control...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is funding research to investigate the role of the glucocorticoid receptor (GR) as a neuromolecular mechanism regulating impulsivity within the prelimbic cortex-nucleus accumbens pathway. The total award amount is $127,635, with a project period from June 17, 2025 to December 31, 2025. The research, conducted by the Regents of the University of Michigan,...
This $4.68 million project grant from the National Institute on Drug Abuse, part of the Department of Health and Human Services, will fund research under the Drug Abuse and Addiction Research Programs (CFDA 93.279). The University of Michigan will conduct a prospective cohort study of 400 adults with opioid-involved polysubstance use in Michigan. Researchers will collect detailed weekly data on participants' substance use patterns and motivations over four weeks to understand nuanced profiles...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), will support a $346,911 cross-species research study to identify early life environmental and genetic risk factors for substance use disorders (SUDs). The key objectives are to: 1) determine how early life environment influences neurocognitive development and its relationship to adult impulsivity behaviors; 2) identify genomic networks associated...
This $265,302 Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to investigate the neural mechanisms underlying opioid use disorder (OUD) and relapse risk during abstinence. The funded project will map the functional and anatomical pathways between the anterior and posterior paraventricular nucleus of the thalamus (PVT) and the nucleus accumbens (NAc), which have been implicated in the...
This federal Project Grant award of $800,617.00, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports the development and validation of neuromarkers - measurable, brain-based indicators of pathophysiology, risk, and resilience related to substance use disorders (SUDs). The project, titled "NEUROMARKERS FOR CRAVING AND DRUG USE", aims to build upon previous research that created a cross-validated neuromarker...
This federal Project Grant award for $634,617, awarded by the National Institute on Drug Abuse (NIDA) under CFDA Program 93.279 - Drug Use and Addiction Research Programs, will support research on the neural basis of the transition from goal-directed to habitual behavior. The primary objectives are to: 1) validate a novel "volitional engagement" behavioral paradigm using techniques like optogenetics and outcome devaluation, 2) monitor and manipulate neural circuits in the...
This Project Grant award of $159,615 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support research to predict craving and relapse in opioid use disorder using neurobehavioral markers of goals and habits. The key objectives are to: Track daily changes in motivational control during inpatient heroin addiction treatment with and without fentanyl use, to understand how goal-directed control evolves with abstinence. Use the...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), will support a $2,075,613 research project conducted by the Regents of the University of Michigan. The project aims to validate a human sign-/goal-tracking paradigm and identify neurobehavioral signatures of sign- and goal-tracking behaviors in emerging adults, which are key to understanding individual differences in addiction liability. The research will assess participants on measures of reward responsivity, attentional control, and impulse control, and use functional MRI to examine brain function related to sign-/goal-tracking and substance use. The long-term goal is to identify early those at highest risk for addiction, which could inform prevention and treatment efforts to limit the transition to addiction, reduce relapse rates, and improve public health. The project period runs from September 2024 through July 2029.